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Small Extracellular Vesicles and Insulin Action

Washington University School of Medicine · NCT05933707

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 25–55 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
72
US sites recruiting
1
Study start
June 14, 2023
Record last updated
July 17, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goals of this research study are to: 1) understand why some people with obesity are protected from developing conditions such as type 2 diabetes and cardiovascular disease while others are more likely to develop obesity-related conditions; 2) assess the effect of small extracellular vesicles (sEVs also called exosomes), obtained from human participants, on metabolic function in cultured cells and in mice.

Being studied: People with Metabolically Unhealthy Obesity - Low Calorie Diet

Conditions: Obesity; Insulin Resistance; Metabolically Healthy Obesity; Obesity, Metabolically Benign

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Metabolically healthy lean subjects must have a BMI ≥18.5 and ≤24.9 kg/m²; Subjects with obesity must have a BMI ≥30.0 and ≤50.0 kg/m²
  • Metabolically healthy lean and people with metabolically healthy obesity must have intrahepatic triglyceride (IHTG) content ≤5%; fasting plasma glucose concentration \<100 mg/dl, 2-hr oral glucose tolerance plasma glucose concentration \<140 mg/dl, hemoglobin A 1C (HbA1c) ≤5.6% and HOMA-IR \<2.5.
  • People with metabolically unhealthy obesity must have intrahepatic triglyceride (IHTG) content ≥5.6%; HOMA-IR ≥2.5, and HbA1c 5.7%-6.4%, or fasting plasma glucose concentration ≥100 mg/dl, or 2-hr oral glucose tolerance test (OGTT) plasma glucose concentration ≥140 mg/dl.

Exclusion Criteria

  • History of diabetes, liver disease other than NAFLD or other serious diseases,
  • Consume excessive amounts of alcohol (>21 units/week for men and >14 units/week for women),
  • Take medications that could affect the study outcome measures, engage in regular exercise (>120 min/week),
  • Are pregnant or lactating

Recruiting US locations

  • Washington University School of Medicine

    St Louis, MO 63110

    Site contact: Kyle Timmons · 314-273-1879 · nutritionresearch@wustl.edu

Study contacts (from the official record)

  • Kyle Timmons · 3142731879 · nutritionresearch@wustl.edu
  • Beth Henk · 3143628250 · bhenk@wustl.edu
All weight loss studies in Missouri →
Small Extracellular Vesicles and Insulin Action (NCT05933707) | Bored Studies