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State of Hormones Impact Nociceptive Expression

University of Alabama at Birmingham · with National Institute of Nursing Research (NINR) · NCT05787470

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
120
US sites recruiting
1
Study start
March 1, 2023
Record last updated
July 2, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The Investigators have recently published on differences in pain sensitivity measures between cis and trans individuals in the local area. The investigators observed the anticipated differences in pain sensitivity between CM and CW (CW > CM), but found that the TW were phenotypically similar to CW in all measures. However, the investigators did not assess hormone level, nor did the investigators recruit TM participants. Here, with the assistance of two local community group stakeholders the investigators will recruit the following groups: CM, CW, TM+T (currently taking exogenous testosterone), TW+E (exogenous estradiol), TM, and TW (n=20/group). The investigators will use quantitative sensory testing to assess sensitivity to cold, pressure, and heat via standardized protocols. Blood samples will be taken for assessment of stress and reproductive hormone levels, immune cell populations and stimulated cytokine release. Finally, questionnaires will measure pain state, quality of life (QOL), voice QOL, body image, appearance, self-reported health, masculinity/femininity, community connectedness, gender role, sleep, depression, social support, adverse childhood experiences and stigma.

Being studied: Quantative sensory testing; Blood Draw

Conditions: Pain; Gender Identity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • self-identification as one of the above gender identities
  • understanding of verbal and written English.
  • participants that have been on/off hormone treatment for at least 6 months

Exclusion Criteria

  • pain in at least 3/7 days/week for the past 3 months
  • HIV positive diagnosis
  • cardiovascular or pulmonary disease
  • regular use of opioid pain medications
  • uncontrolled hypertension (i.e. SBP/DBP of > 150/95)
  • current illness accompanied by fever (body temperature >38 °C)
  • prostatectomy, hysterectomy or oophorectomy
  • hospitalization due to psychiatric illness within the last 6 months.

Recruiting US locations

  • University of Alabama at Birmingham

    Birmingham, AL 35294

    Site contact: Tammie Quinn, BA · (205) 934-8743 · tquinn@uab.edu

Study contacts (from the official record)

  • Tammie Quinn, BA · (205) 934-8743 · tquinn@uab.edu
All healthy volunteers studies in Alabama →
State of Hormones Impact Nociceptive Expression (NCT05787470) | Bored Studies