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Study of Circulating Monocytes in Patients With Ischemic Vascular Disease

UConn Health · NCT04321512

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
300
US sites recruiting
1
Study start
December 1, 2013
Record last updated
August 17, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this research study is to discover the functions of circulating white blood cells, called monocytes, and associated circulating substances in heart attack and ischemic stroke patients. Ischemic Strokes (clots) occur as a result of an obstruction within a blood vessel supplying blood to the brain. A type of monocyte carrying a surface marker called "P2X4" helps the immune system sense and respond to danger signals from the body such as heart muscle and brain tissue injuries.

The researchers expect to learn more about how these monocyte cells react to heart and brain tissue injury, and how the cells may then produce proteins or other chemical substances which promote the healing of heart muscle after heart attack and brain tissue after an ischemic stroke.

Being studied: There is no intervention given to the subjects

Conditions: Myocardial Infarction; Stroke, Ischemic; Ischemia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • STEMI Patients: Men and women aged 18 years and over, with symptoms, physical signs and ECG changes characteristic of STEMI.
  • NSTEMI Patients: Men and women aged 18 years and over, with symptoms, physical signs and ECG changes characteristic of NSTEMI.
  • Stable CAD Patients: men and women aged 18 years and older with coronary artery disease proven by prior MI history, angiography or stress test but without any unstable angina or acute coronary syndrome.
  • Ischemic Stroke Patients: Men and women aged 18 years and over, with symptoms, physical signs and CT/MRI changes characteristic of ischemic stroke.
  • Healthy Controls: Men and women aged 18 years and over, without heart failure, coronary disease, hypertension, diabetes or other chronic diseases. Control subjects will be recruited from within the community of UConn Health via advertisement.

Exclusion Criteria

  • Subjects who are unable to give informed consent (with the exception of the ischemic stroke arm patients, see Protocol Design below) and pregnant subjects.
  • Subjects who had any history of embolic, ischemic or hemorrhagic stroke within the last 12 months.

Recruiting US locations

  • University of Connecticut Health Center

    Farmington, CT 06030

    Site contact: Adrianna Perez · 860-679-7549 · adrperez@uchc.edu

Study contacts (from the official record)

  • Kristen Siedlarz, MA · 860-679-7549 · siedlarz@uchc.edu
  • Adrianna G. Perez · adrperez@uchc.edu
All heart & blood pressure studies in Connecticut →
Study of Circulating Monocytes in Patients With Ischemic Vascular… (NCT04321512) | Bored Studies