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RecruitingPhase 1

Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy

Consano Bio · NCT07264270

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–70 · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 1
Target enrollment
24
US sites recruiting
2
Study start
December 3, 2025
Record last updated
October 21, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to evaluate the safety and tolerability of C-1101 administered as a single dose, transforaminal epidural injection compared to sterile saline

Being studied: C-1101; Placebo: Sterile Saline

Conditions: Lumbosacral Radicular Pain; Sciatic Radiculopathy; Sciatic Leg Pain; Sciatica; Lumbosacral Radicular Syndrome; Lumbosacral Radiculopathy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Diagnosis of painful LSR (sciatica) radiating to or below the knee, with an inadequate response to conservative care
  • Body mass index \< 40 kg/m2.

Exclusion Criteria

  • Presence of clinically significant disease or any other painful condition that may interfere with assessments.
  • Any condition that currently requires blood or platelet transfusions.
  • Diagnosed with schizophrenia, bipolar disorder, or major depressive disorder.
  • Increased risk of bleeding or is taking anticoagulants or platelet aggregation inhibitors.
  • History or presence of autonomic neuropathy, diabetic neuropathy, or other peripheral neuropathies.
  • History of myocardial infarction within the last 6 months or congestive heart failure.
  • The presence of an active malignancy or tumor.
  • Have undergone a surgical procedure for back pain.
  • Recent use of immunosuppressants, oral steroids, or intravenous steroids.

Recruiting US locations

Study contacts (from the official record)

  • Senior Director, Clinical Development Operations · U.S.:+1-508-492-0599 · ClinicalDev@consanobio.com
  • AUS Clinical Development Operations · AUS: +61 8 8361 3222 · ClinicalDev@consanobio.com
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Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults… (NCT07264270) | Bored Studies