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RecruitingAccepts healthy volunteersEarly Phase 1

Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

University of Texas Southwestern Medical Center · NCT04838678

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–55 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
100
US sites recruiting
1
Study start
July 18, 2021
Record last updated
September 3, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.

Being studied: Neuropeptide Y

Conditions: Hypertension; Obesity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Control - BMI\<30, age 18-55
  • Hypertensive - BMI\<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI>30, age 18-55 Obese-hypertensive- BMI>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring

Exclusion Criteria

All groups - presence of other significant cardiovascular disease, renal disease, history of smoking, diabetes,

Recruiting US locations

  • University of Texas Southwestern Medical Center

    Dallas, TX 75231

    Site contact: CHristopher Hearon · 8155405612 · christopherhearon@texashealth.org

Study contacts (from the official record)

  • Christopher M Hearon, Ph.D. · 214-345-4624 · christopher.hearon@utsouthwestern.edu
  • Mary Childers · 214-345-6459 · marychilders@texashealth.org
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Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN) (NCT04838678) | Bored Studies