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tACS to Enhance Language Abilities

University of Pennsylvania · NCT06092814

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–85 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
120
US sites recruiting
1
Study start
July 12, 2024
Record last updated
August 24, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and sham tACS in conjunction with various language tests. Researchers will compare the post-stroke aphasia group with aged matched controls to see if brain response to tACS differs between groups.

Being studied: Active transcranial alternating current stimulation (tACS)

Conditions: Stroke; Aphasia, Acquired; Aphasia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria for Persons with Aphasia:

  • Presence of aphasia
  • Suffered a single, left hemisphere stroke
  • Stroke ≥6 months old (chronic) at the time of enrollment

Inclusion Criteria for Healthy Controls

  • Right-handedness
  • Must be able to understand the nature of the study, and give informed consent

Exclusion criteria for Persons with Aphasia:

  • Inability to understand the nature of the study
  • Marked naming impairment
  • Impaired non-verbal, conceptual processing
  • History of significant medical or neurological disorder (other than stroke)
  • History of significant or poorly controlled psychiatric disorders
  • Current abuse of alcohol or drugs, prescription or otherwise
  • Nursing a child, pregnancy, or intent to become pregnant during the study
  • Clinically significant hearing loss
  • Contraindications to tACS
  • Contraindications to MRI

Exclusion Criteria for Healthy Controls

  • Diagnosis of a neurodegenerative disease or clinically significant cognitive complaint
  • Any unrelated neurologic or physical condition that impairs communication ability
  • History of unrelated neurological conditions including but not limited to traumatic brain injury, stroke, or small vessel disease that has resulted in a neurologic deficit
  • Any additional neurological condition that would likely reduce the safety of study participation, including central nervous system (CNS) vasculitis, intracranial tumor, intracranial aneurysm, multiple sclerosis or arteriovenous malformations
  • A medically unstable cardiopulmonary or metabolic disorder
  • Terminal illness associated with survival \<12 months
  • Major active psychiatric illness that may interfere with required study procedures or treatments as determined by the enrolling physician
  • Current abuse of alcohol or drugs, prescription or otherwise
  • Contraindications to tACS
  • Contraindications to MRI

Recruiting US locations

  • University of Pennsylvania

    Philadelphia, PA 19104

    Site contact: Denise Harvey, PhD · 215-573-4336 · harveyde@pennmedicine.upenn.edu

Study contacts (from the official record)

  • Daniela Sacchetti, MS · 215 573 4336 · danielas@pennmedicine.upenn.edu
  • Denise Harvey, PhD · 215 573 4336 · harveyde@pennmedicine.upenn.edu
All neurology studies in Pennsylvania →
tACS to Enhance Language Abilities (NCT06092814) | Bored Studies