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Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF

University of Texas Southwestern Medical Center · NCT05723679

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 55–90 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
78
US sites recruiting
1
Study start
July 1, 2023
Record last updated
May 7, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity. As per investigator's hypothesis, obesity is likely a significant contributor to DOE and exercise intolerance in patients with HFpEF.

Being studied: HeO2 gas mixture; Room air gas mixture

Conditions: Heart Failure With Preserved Ejection Fraction; Obesity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • signs and symptoms of heart failure
  • an ejection fraction > 0.50;
  • objective evidence of diastolic dysfunction. elevated biomarkers (NT-proBNP >300 ng/dl) or HF hospitalization
  • healthy volunteers

Exclusion Criteria

  • age \< 55 years
  • BMI > 50 kg/m2
  • Atrial fibrillation with poorly controlled heart rate
  • phosphodiesterase type 5 (PDE5) inhibitor use
  • severe valvular disease
  • severe Chronic obstructive pulmonary disease (COPD)
  • Chronic kidney disease (CKD) 4 or higher
  • any restriction of ambulation and mobility.

Recruiting US locations

  • UT Southwestern Medical Center

    Dallas, TX 75390

    Site contact: Raksa B Moran, RN · 2143456574 · raksamoran@texashealth.org

Study contacts (from the official record)

  • Raksa B Moran, RN · 214-345-6574 · raksamoran@texashealth.org
  • Jessica N Alcala, RN · 214-345-6574 · jessicaalcala@texashealth.org
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Targeting Breathing Limitations to Improve Functional Outcomes in… (NCT05723679) | Bored Studies