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Tau PET in Imaging and Cognition: Healthy Adults From 55-90

Yaakov Stern · with National Institute on Aging (NIA) · NCT03372317

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 55–90 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
105
US sites recruiting
1
Study start
June 1, 2018
Record last updated
February 11, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The investigators aim to use the new PET radioligand, 18F-MK-6240, to detect tau pathology in cognitive healthy and mild cognitive impairment (MCI) elders. The investigators will then examine the interactions between differential tau burden and performance on cognitive tasks, functional magnetic resonance imaging (fMRI) neural activation patterns, and other cognitive and behavioral measures. By investigating these relationships, the investigators hope to understand the cognitive and behavioral outcomes of tau deposition found in specific brain regions in cognitively normal/mildly cognitively impaired adults. Furthermore, the study aims to examine how the presence of tau may contribute to the risk of subsequent cognitive decline, neurodegeneration, and dementia.

Being studied: 18F-MK-6240

Conditions: Mild Cognitive Impairment; Aging

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Aged 55-90
  • Previously received an amyloid PET scan
  • Residing near Columbia University Medical Center
  • Must be willing and able to participate

Exclusion Criteria

  • Have a contraindication to PET (e.g, metallic implants, pacemaker, claustrophobia, or cannot lie flat for one hour)
  • Pregnancy
  • Lactating Women
  • Current, past, or anticipated exposure to radiation
  • Significant active physical illness

Recruiting US locations

  • Columbia University Medical Center

    New York, NY 10032

    Site contact: Ashley Mensing, BS · 212-305-6314 · ao2454@cumc.columbia.edu

Study contacts (from the official record)

  • Reshma Babukutty · 212-305-6314 · rb2996@cumc.columbia.edu
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Tau PET in Imaging and Cognition: Healthy Adults From 55-90 (NCT03372317) | Bored Studies