Skip to content
Bored Studies
RecruitingAccepts healthy volunteers

Tear Fluid for the Detection of Tumor-associated Extracellular Vesicles in Glioblastoma Patients

City of Hope Medical Center · with National Cancer Institute (NCI) · NCT07775534

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
30
US sites recruiting
1
Study start
December 9, 2026
Record last updated
October 8, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This clinical trial tests the impact of tear fluid in detecting tumor-associated extracellular vesicles (TEVs) in patients with glioblastoma. Brain tumors release small particles, called TEVs, that may provide information about the tumor, including how it responds to treatment. These particles can be found in cerebrospinal fluid (CSF), which is the fluid that surrounds the brain and spinal cord. Collecting CSF can be difficult and expensive, especially if samples are needed frequently to track these particles over time. Tear fluid is easier to collect than spinal fluid. If tears are found to contain similar tumor-related particles, changes in the tumor may be tracked by studying the particles found in tear fluid.

Being studied: Biospecimen Collection; Biospecimen Collection; Electronic Health Record Review; Questionnaire Administration

Conditions: Glioblastoma

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adults (age ≥ 18)
  • Male and female
  • All racial and ethnic groups
  • Pathologically-proven diagnosis of GBM or healthy volunteers
  • For GBM patients, presence of a previously placed Rickham reservoir or shunt
  • Able to provide informed consent (or via legal representative)
  • Willing to undergo Schirmer strip procedure

Exclusion Criteria

  • Active ocular infection or inflammation
  • Recent ocular surgery (within 3 months)
  • Chronic dry eyes
  • Known allergy or hypersensitivity to topical anesthetics
  • Cognitive impairment
  • Pregnancy
  • Any condition that, in the opinion of the investigator, would interfere with the participant's ability to comply with study procedures or place the participant at undue risk

Recruiting US locations

  • City of Hope Medical Center

    Duarte, CA 91010

    Site contact: Lisa A. Feldman · 626-218-8680 · lfeldman@coh.org

All healthy volunteers studies in California →
Tear Fluid for the Detection of Tumor-associated Extracellular… (NCT07775534) | Bored Studies