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The Cardiovascular Impact of Hot Flushes

University of Minnesota · NCT05251324

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 40–70 · Women only
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
60
US sites recruiting
1
Study start
March 1, 2022
Record last updated
May 7, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The overall objective of this study is to examine the physiological responses that occur during a hot flush in postmenopausal women. The following specific aims will be executed to reach the overall objective of this study. Aim 1: To determine if hot flushes can be reliably induced with a temperature-controlled, water- circulating (TCWC) heating pad. Based on previous research, the investigators hypothesize that hot flushes will be inducible with the TCWC in symptomatic women, but not in asymptomatic women. Aim 2: To determine if heat-induced hot flushes in symptomatic women will cause reproducible cardiovascular and respiratory responses. The investigators hypothesize that heat-induced hot flushes produce similar and reproducible cardiovascular and respiratory responses to spontaneous hot flushes. Aim 3: To determine if body fat percentage influences hot flush severity or frequency during spontaneous or induced hot flushes. The investigators hypothesize that women with higher body fat have reduced hot flash severity and frequency.

Being studied: Hot Flush Induction

Conditions: Hot Flashes; Menopause

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Postmenopausal (may have or may not have hot flushes)
  • Have not started hormone therapy and/or will discontinue hormone therapy for the duration of the study

Exclusion Criteria

  • Reported nicotine/tobacco use within the last six months
  • Diabetic or asthmatic
  • Diagnosed significant carotid stenosis
  • History of significant autonomic dysfunction, heart disease, respiratory disease, or severe neurologic condition such as stroke or traumatic brain injury
  • Existing metabolic or endocrine abnormalities
  • Use of heart/blood pressure medications that are determined to interfere with study outcomes
  • Unwilling to discontinue use of OC (or other hormonal contraceptives, including intrauterine devices or contraceptive implants) and/or MHT
  • Pregnant or breastfeeding
  • Unwilling or unable to refrain from consuming caffeine or alcohol in the 12 hours before visit two or three
  • Unwilling or unable to refrain from vigorous exercise (at least 10 minutes in duration) in the 12 hours before visit two or three
  • Unwilling or unable to fast in the eight hours before visit two or three
  • Body mass index greater than or equal to 35 kg/m\^3

Recruiting US locations

Study contacts (from the official record)

  • Manda Keller-Ross, PhD, DPT, PT · (612) 625-3175 · kell0529@umn.edu
  • William Stokes · (443) 801-8778 · stoke123@umn.edu
All women’s health studies in Minnesota →
The Cardiovascular Impact of Hot Flushes (NCT05251324) | Bored Studies