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The Effects of Exercise on Immune Phenotype of Indolent Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia Patients

Mayo Clinic · NCT05876923

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–80 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
70
US sites recruiting
2
Study start
June 12, 2023
Record last updated
April 9, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This clinical trial studies the effect of short-term (acute) and long-term (chronic) exercise on immune characteristics and function (phenotype) of patients with indolent non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL). Most newly-diagnosed CLL patients have early-stage disease at the time of diagnosis and do not require treatment. Despite not needing therapy, these patients have significant immune dysfunction. This may lead to an increased risk of serious infections requiring hospitalization and an increased risk of secondary non-blood-based (hematologic) cancers. Increasing CLL patients overall physical fitness levels, through exercise during the observation stage, may provide a realistic approach means to increase survival, decrease treatment-related side effects, and improve immune function. Information learned from this study may help researchers determine whether a particular exercise regimen can be used to strengthen the immune system of indolent NHL and CLL patients, delay time to disease progression, assess the need for treatment, and assess infection rates.

Being studied: Biospecimen Collection; Cardiopulmonary Exercise Testing; Dual X-ray Absorptiometry; Electronic Health Record Review; Exercise Intervention; Physical Examination; Questionnaire Administration; Spirometry; Physical Performance Testing; Best Practice

Conditions: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma; Indolent Non-hodgkin Lymphoma

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • English speaking
  • Between the ages of 18-80
  • Histologically confirmed diagnosis of indolent non-Hodgkin lymphoma (NHL) will be required to participate in Aim 2 (CLL/SLL only), aim 3 and 4 (indolent NHL) and aim 5 (indolent NHL) of this study

Exclusion Criteria

  • Healthy subjects participating in Aim 1 will be excluded if they have known cardiovascular or pulmonary disease (e.g. heart disease, coronary artery disease, chronic obstructive pulmonary disease [COPD], asthma, etc.) an orthopedic or musculoskeletal limitation which would limit ability to exercise or are a current or former smoker
  • Indolent NHL individuals receiving treatment must have least 8 weeks of planned treatment remaining and those who have already received treatment must be at least 6 months post and have no planned treatments during the 12-week intervention period to be eligible. Individuals that are participating prior to receiving treatment must not have any scheduled treatments during their participation. Individuals will be excluded if they have uncontrolled hypertension, cardiac illness, or are not approved by their oncologist to participate

Recruiting US locations

  • Mayo Clinic in Arizona

    Scottsdale, AZ 85259

    Site contact: Clinical Trials Referral Office · 855-776-0015 · mayocliniccancerstudies@mayo.edu

  • Mayo Clinic in Rochester

    Rochester, MN 55905

    Site contact: Clinical Trials Referral Office · 855-776-0015 · mayocliniccancerstudies@mayo.edu

Study contacts (from the official record)

  • Clinical Trials Referral Office · 855-776-0015 · mayocliniccancerstudies@mayo.edu
  • Courtney Wheatley-Guy, PhD · 480-301-8976 · wheatley.courtney@mayo.edu
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The Effects of Exercise on Immune Phenotype of Indolent… (NCT05876923) | Bored Studies