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The Heartland Study

Heartland Health Research Alliance · with Indiana University · NCT05492708

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · Women only
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
2600
US sites recruiting
3
Study start
January 11, 2020
Record last updated
June 29, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The Heartland Study is a prospective, observational study that will enroll up to 2,600 pregnant participants across the Heartland States in the U.S..

The objective of the Heartland Study is to address major knowledge gaps concerning the health effects of herbicides on maternal and infant health. The study is being conducted to evaluate the associations between environmental exposures to herbicides during and after pregnancy and reproductive health outcomes. The study is measuring multiple biomarkers of herbicide exposure among pregnant Midwesterners and their partners to evaluate associations with pregnancy and childbirth outcomes, epigenetic biomarkers of exposure, and child development.

Conditions: Pregnancy Related; Pregnancy Complications; Birth Defect; Gestational Age and Weight Conditions; Spontaneous Abortion; Miscarriage; Exposure to Herbicides

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Pregnant persons ages 18 or older at time of consent who are ≤20+6 weeks pregnant. Best clinical estimate of gestational age will be utilized for recruitment purposes. Enrollment in the first trimester (≤ 13 + 6) is preferred, but anyone ≤ 20 +6 is permitted.
  • Living in one of the 13 Heartland Study region states at the time of enrollment (Arkansas, Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota, or Wisconsin) Optional inclusion of the putative biological father

Exclusion Criteria

  • Participants who are not fluent in and/or do not fully understand, read, write, or speak the English language.
  • Other inability to provide informed consent to participate

Recruiting US locations

  • Indiana University Medical Center

    Indianapolis, IN 46202

    Site contact: Kathleen Flannery · hhra@iu.edu

  • University of Iowa Health Care

    Iowa City, IA 52242

    Site contact: Donna Santillan, PhD

  • Marshfield Clinic

    Marshfield, WI 54449

    Site contact: Melissa Slager · HeartlandStudy@marshfieldresearch.org

Study contacts (from the official record)

  • Kathleen Flannery · 317-880-3961 · kamaflan@iu.edu
All pregnancy studies in Indiana →
The Heartland Study (NCT05492708) | Bored Studies