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RecruitingAccepts healthy volunteersPhase 4

The Impact of Dietary Salt on the Severity of Eczema

University of California, San Francisco · with United States Department of Defense · NCT07447063

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
40
US sites recruiting
2
Study start
August 10, 2026
Record last updated
September 10, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to evaluate the feasibility of low-sodium diet to improve eczema severity. The main questions it aims to answer are:

  • Does a low-sodium diet improve eczema severity?
  • How does a low-sodium diet impact skin sodium concentration?
  • Is skin sodium concentration associated with eczema severity?

Researchers will ask all participant to follow a low-sodium diet, then compare sodium tablets to a placebo (a look-alike substance that contains no drug) to specifically examine the impact of altering sodium intake.

Participants will

  • Follow a low-salt diet for the duration of the 24-week study
  • Take sodium chloride tablets every day for 5 weeks followed by a placebo every day for 5 weeks after a 2-week washout period, or vice versa
  • Complete up to 4 virtual check-in visits
  • Visit the clinic 4 times to answer questionnaires, provide bio samples, complete dietary recalls, and undergo non-contrast sodium MRI

Being studied: Sodium chloride tablets; Placebo Tablets

Conditions: Eczema; Atopic Dermatitis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Participants ages 18 years
  • Willing and able to undergo non-contrast MRI.

Exclusion Criteria

  • Contraindications to MRI (such as cardiac pacemakers, claustrophobia, non-compatible intracranial vascular clips, IUDs, or other implants)
  • A cardiac event in the past 6 months
  • Impaired function of the liver or kidney (glomerular filtration rate \<60 mL/min)
  • Medications that influence sodium excretion (e.g., diuretics or SGLT2 inhibitors)
  • Antibiotic or immunomodulatory medications within the last month
  • Contraindications to sodium tablets

(Topical medications used exclusively on the head/neck or hands/feet (e.g., antifungal nail treatment, antidandruff shampoo, acne cleansers) are acceptable. Topical and systemic eczema treatments are acceptable if the participant has been on a stable dose for at least 2 months and still meets the severity entry criteria. Patients on dupilumab will not be excluded if they have been on dupilumab for at least two months and still meet the disease severity inclusion criteria.)

Recruiting US locations

  • San Francisco VA Medical Center

    San Francisco, CA 94115

    Site contact: Alicia Hamblin, BS · Alicia.Hamblin@ucsf.edu

  • UCSF Mt Zion Campus

    San Francisco, CA 94511

    Site contact: Alicia Hamblin, BS · Alicia.Hamblin@ucsf.edu

Study contacts (from the official record)

  • Alicia Hamblin, BS · 925-549-7889 · Alicia.Hamblin@ucsf.edu
  • Katrina Abuabara, MD · 415-514-9769 · katrina.abuabara@ucsf.edu
All dermatology studies in California →
The Impact of Dietary Salt on the Severity of Eczema (NCT07447063) | Bored Studies