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RecruitingAccepts healthy volunteersPhase 4

The Impact of Salt Intake on Sodium in the Skin and Inflammatory Skin Disease

University of California, San Francisco · with LEO Foundation · NCT07487831

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
50
US sites recruiting
2
Study start
July 14, 2026
Record last updated
September 9, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to demonstrate the feasibility of a trial that examines the impact of changes in dietary sodium intake on skin sodium levels, atopic dermatitis, and psoriasis. In addition, it aims to generate preliminary data to begin to answer the following questions:

  • Is there an association between skin sodium concentration and atopic dermatitis and psoriasis severity?
  • Are changes in dietary sodium are associated with changes in skin sodium concentration and atopic dermatitis and psoriasis severity?

Researchers will compare sodium tablets to a placebo (a look-alike substance that contains no drug) to specifically examine the impact of altering sodium intake.

Participants will

  • Follow a low-salt diet for the duration of the 13-week study
  • Take sodium chloride tablets every day for 5 weeks followed by a placebo every day for 5 weeks after a 2-week washout period, or vice versa
  • Visit the clinic up to 4 times to answer questionnaires, provide bio samples, complete dietary recalls, and undergo non-contrast sodium MRI

Being studied: Sodium chloride tablets; Placebo Tablets

Conditions: Atopic Dermatitis (Eczema); Psoriasis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Participants ages 18 years
  • Willing and able to undergo non-contrast MRI.

Exclusion Criteria

  • Contraindications to MRI (such as cardiac pacemakers, claustrophobia, non-compatible intracranial vascular clips, IUDs, or other implants)
  • A cardiac event in the past 6 months
  • Impaired function of the liver or kidney (glomerular filtration rate \<60 mL/min)
  • Medications that influence sodium excretion (e.g., diuretics or SGLT2 inhibitors)
  • Antibiotic or immunomodulatory medications within the last month
  • Contraindications to sodium tablets

(Topical medications used exclusively on the head/neck or hands/feet (e.g., antifungal nail treatment, antidandruff shampoo, acne cleansers) are acceptable. Topical and systemic eczema treatments are acceptable if the participant has been on a stable dose for at least 2 months and still meets the severity entry criteria. Patients on dupilumab will not be excluded if they have been on dupilumab for at least two months and still meet the disease severity inclusion criteria.)

Recruiting US locations

  • UCSF Mt Zion Campus

    San Francisco, CA 94115

    Site contact: Alicia Hamblin · 925-549-7889 · Alicia.Hamblin@ucsf.edu

  • San Francisco VA Medical Center

    San Francisco, CA 94121

    Site contact: Alicia Hamblin · 925-549-7889 · Alicia.Hamblin@ucsf.edu

Study contacts (from the official record)

  • Alicia Hamblin · 925-549-7889 · Alicia.Hamblin@ucsf.edu
  • Katrina Abuabara, MD · 415-514-9769 · katrina.abuabara@ucsf.edu
All dermatology studies in California →
The Impact of Salt Intake on Sodium in the Skin and Inflammatory… (NCT07487831) | Bored Studies