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The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS)

VA Office of Research and Development · NCT05926102

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 55–69 · Men only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
5000
US sites recruiting
1
Study start
February 1, 2024
Record last updated
January 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Prostate cancer is the most common non-skin cancer among Veterans and the second leading cause of male cancer death. Current methods of screening men for prostate cancer are inaccurate and cannot identify which men do not have prostate cancer or have low-grade cases that will not cause harm and which men have significant prostate cancer needing treatment. False-positive screening tests can result in unnecessary prostate biopsies for men who do not need them. However, new genetic testing might help identify which men are at highest risk for prostate cancer. This study will examine whether a genetic test helps identify men at risk for significant prostate cancer while helping men who are at low risk for prostate cancer avoid unnecessary biopsies. If this genetic test proves beneficial, it will improve the way that healthcare providers screen male Veterans for prostate cancer.

Being studied: Precision screening intervention; Usual care

Conditions: Prostate Cancer

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • baseline age 55-69 years
  • receipt of regular VA care
  • Veteran status

Exclusion Criteria

  • personal history of prostate cancer
  • prior prostate biopsy, prostatectomy, or prostate MRI
  • known carrier status of rare variant associated with cancer syndrome

Recruiting US locations

  • VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

    Boston, MA 02130-4817

    Site contact: Charles A Brunette, PhD · 857-364-6324 · charles.brunette@va.gov

Study contacts (from the official record)

  • Charles A Brunette, PhD · (857) 364-6324 · charles.brunette@va.gov
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The Prostate Cancer, Genetic Risk, and Equitable Screening Study… (NCT05926102) | Bored Studies