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The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies

University of California, San Francisco · with National Institutes of Health (NIH) · NCT01202305

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–70 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
50
US sites recruiting
1
Study start
April 2011
Record last updated
May 1, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

HIV medicines have led to dramatic improvements in health. However, there remains a concern for potential drug toxicities, cost of drugs, and need for life-long treatment. In addition, research has found that health is not completely restored in HIV-infected patients, even if they have been taking effective HIV medicines for a long time. This may be due to direct drug-toxicity, continued replication of the virus, and/or inflammation of the body in response to the virus. Therefore, a more complete understanding of how HIV stays in the body is necessary.

Recent research has shown that one of the places that HIV can stay in the body is in lymphatic tissues such as lymph nodes (even in patients who have been taking HIV medicines for a long time). In addition, the amount of damage to the lymphatic tissues can predict how the immune system (CD4+ T cell count) will respond to therapy.

The investigators therefore propose a study in which lymph nodes from the groin area will be removed, with the goals of: 1) seeing how much HIV is in lymph nodes and 2) seeing how much damage has happened to the lymph node architecture.

Being studied: Lymph node biopsy

Conditions: HIV

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Able to give informed consent
  • No contraindication to surgical procedures
  • Palpable inguinal adenopathy at study entry
  • For HIV seropositive subjects, meeting one of the following criteria: (1) on stable highly active antiretroviral therapy (HAART) with a recent undetectable viral load (\< 50 copies/mL) ("HAART suppressed"), (2) antiretroviral untreated with an undetectable viral load (\< 50 copies/mL) ("elite" controllers), or (3) antiretroviral untreated with a detectable viral load (> 1000 copies/mL) ("non-controllers")

Exclusion Criteria

  • Known anemia (HIV+ males Hct\<34; females Hct\<32) or contraindication to donating blood
  • Blood coagulation disorder (including bleeding tendency or problems in past with blood clots)
  • Platelets \< 50,000/mm3
  • PTT > 2x ULN
  • INR > 1.5
  • Pregnant

Recruiting US locations

  • San Francisco General Hospital

    San Francisco, CA 94110

    Site contact: Marian Kerbleski, RN · 415-476-4082 · Marian.Kerbleski@ucsf.edu

Study contacts (from the official record)

  • Rebecca Hoh, RD · 415-502-2453 · Rebecca.Hoh@ucsf.edu
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The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies (NCT01202305) | Bored Studies