Topical Netarsudil for the Prevention of Proliferative Vitreoretinopathy in Patients With Retinal Detachment

The primary rhegmatogenous detachment cohort will have the following selection criteria:

Inclusion criteria

• Patients > 18 years old
• Patients presenting for primary rhegmatogenous retinal detachment repair within 28 days of symptom onset
• Patients undergoing vitrectomy or vitrectomy with scleral buckle

Exclusion criteria

• Patient unable to give consent
• Patient unable to follow-up
• Prior history of retinal detachment incisional surgery in presenting eye
• Prior history of open globe injury to presenting eye
• Prior history of glaucoma surgery to presenting eye I.e., Status post trabeculectomy, Ahmed tube placement, minimally invasive glaucoma surgery, actively on glaucoma medication
• Prior history of corneal disease, or history of corneal edema
• Patient already on topical netarsudil in presenting eye
• Patient without natural lens or intraocular lens implant (I.e., aphakic patients)
• Patients with intraocular pressure \<8mm Hg in operative eye
• Active or chronic or recurrent uncontrolled ocular or systemic disease
• Active or history of chronic or recurrent inflammatory eye disease
• Diagnosis of proliferative diabetic retinopathy
• Signs of ocular infection at presentation in either eye
• Known or suspected sensitivity or allergy to any of the medications used in the operation or postoperatively
• Inability to use/ apply topical eye drops

The proliferative vitreoretinopathy cohort will have the following selection criteria:

Inclusion criteria

• Patients > 18 years old
• Patient presenting with retinal detachment due with proliferative vitreoretinopathy (grade C or higher) or retinal detachment associated with open globe trauma
• Patients undergoing vitrectomy or vitrectomy with scleral buckle

Exclusion criteria

• Patient unable to give consent
• Patient unable to follow-up
• Prior history of glaucoma surgery to presenting eye I.e., Status post trabeculectomy, Ahmed tube placement, minimally invasive glaucoma surgery
• Patient already on topical netarsudil in presenting eye
• Patients with intraocular pressure \<8mm Hg in operative eye
• Active or chronic or recurrent uncontrolled ocular or systemic disease
• Active or history of chronic or recurrent inflammatory eye disease
• Diagnosis of severe nonproliferative or proliferative diabetic retinopathy or vasoproliferative disease in operative eye
• Signs of ocular infection at presentation in either eye
• Known or suspected sensitivity or allergy to any of the medications used in the operation or postoperatively
• Inability to use/ apply topical eye drops
• No Light Perception vision in operative eye
• Failure to achieve intraoperative reattachment