Tranexamic Acid in Rhinoplasty: Perioperative Bleeding, Edema and Ecchymosis
Vanderbilt University Medical Center · NCT05774717
Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.
Key facts
- Compensation
- Not posted. Ask the study team before screening.
- Who can join
- Ages 18+ · All sexes
- Healthy volunteers
- Accepted
- Study type
- Interventional · Phase 1
- Target enrollment
- 60
- US sites recruiting
- 1
- Study start
- April 1, 2023
- Record last updated
- May 7, 2026
Status re-checked against ClinicalTrials.gov within the last 12 hours.
What the study is about
This study will be a prospective randomized study to evaluate the effect of tranexamic acid (TXA) use on intraoperative and postoperative outcomes among patients undergoing rhinoplasty by two Facial Plastic surgeons at Vanderbilt. Outcomes will include intra- and post-operative bleeding and postoperative bruising and swelling.
Being studied: Tranexamic acid
Conditions: Surgery; Postoperative Blood Loss
Eligibility criteria
Copied from the official record. The study team makes the final decision at screening.
Show full criteria
Inclusion Criteria
- Adults at least 18 years of age who elect to undergo cosmetic or functional open primary rhinoplasty with osteotomies (repositioning the nasal bones) by Drs. Yang or Patel at VUMC.
- No other facial plastics procedure nor sinus surgery performed simultaneously
- Lack all the below Exclusion Criteria
Exclusion Criteria
- Known allergy to TXA (tranexamic acid)
- Intracranial bleeding
- Known defective color vision
- History of venous or arterial thromboembolism
- Active thromboembolic disease
- Severe renal impairment (diagnosis of chronic kidney disease)
- History of coagulation disorder
- Known thrombocytopenia (platelets \<150,000)
- Current use of anticoagulant (blood thinner)
- Uncontrolled DM (diabetes mellitus) preventing use of dexamethasone in the perioperative period
- Cardiac arrhythmia
- History of AMI (acute myocardial infarction), stroke, seizure, liver failure
- Laboratory results showing platelets \<150,000, PT (prothrombin time) >45, INR (international normalized ratio) >1.2, seizure disorder
Recruiting US locations
Vanderbilt University Medical Center
Nashville, TN 37232
Site contact: Shiayin F Yang, MD · (615) 322-6180 · elizabeth.d.stephenson.1@vumc.org
Study contacts (from the official record)
- Shiayin F Yang, MD · (615) 322-6180 · jaclyn.lee.1@vumc.org
- Jaclyn Lee, MD · (615) 322-6180 · jaclyn.lee.1@vumc.org
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