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RecruitingAccepts healthy volunteersPhase 4

Vancomycin in TKAs

University of California, San Diego · NCT07282782

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
30
US sites recruiting
1
Study start
June 10, 2024
Record last updated
June 3, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Periprosthetic joint infection (PJI) is a national health crisis and leads to very poor outcomes for patients undergoing elective joint replacement. Within the realm of elective total knee arthroplasty (TKA), various methods of infection prophylaxis are in place. These include sterile precautions, would/tissue handling, and antibiotic prophylaxis. With respect to the latter, various approaches have been utilized including intravenous and intraosseous administration of vancomycin, preoperatively. Intraosseous administration does require another wound and a specific device to administer. The investigators proposed that intraarticular injection of vancomycin is non-inferior to intraosseous administration, thus reducing wounds, time, and cost.

Being studied: Vancomycin

Conditions: Total Knee Arthroplasty

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Any patient over the age of 18 years of age receiving treatment at UC San Diego Health
  • Undergoing primary unilateral TKA
  • Ability to provide consent

Exclusion Criteria

  • previous surgery on the knee (with the exception of arthroscopy)
  • BMI > 35
  • contraindication to receiving vancomycin, cefepime or cefazolin (ie, allergy, etc)
  • diabetics with A1c>7.5% (unless controlled fructosamine)
  • immunocompromised or immunosuppressed patients (HIV, Hepatitis C, end stage renal disease (ESRD), post transplant, chemotherapy or radiation therapy within 6 months of surgery, immunomodulating meducations)
  • no history of active infections
  • no history of chronic kidney disease

Recruiting US locations

  • University of California, San Diego

    San Diego, CA 92093

    Site contact: Dominic Baun, MS · 858-534-8268 · jbaun@health.ucsd.edu

Study contacts (from the official record)

  • Dominic Baun · 858-534-8268 · jbaun@health.ucsd.edu
All healthy volunteers studies in California →
Vancomycin in TKAs (NCT07282782) | Bored Studies