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Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection

Tufts Medical Center · with 4DMedical · NCT05866952

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–99 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
40
US sites recruiting
1
Study start
June 5, 2023
Record last updated
July 20, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Prospective cohort study to evaluate the utility of quantitative CT analysis to assess ventilation and perfusion defects in patients with Post-acute Sequelae of SARS-CoV-2 (PASC) and functional limitations

Being studied: Computed Tomography of the Chest

Conditions: Post-Acute COVID-19; Post COVID-19 Condition; Post Viral Fatigue; Dyspnea

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age ≥ 18
  • Self-reported or documented SARS-CoV-2 infection by RT-PCR or Antigen testing > 3 months ago or no previous history of SARS-CoV-2 infection (control group only)
  • Normal or mild abnormalities on baseline Pulmonary Function Tests (PFTs)
  • New or worsening symptoms of chronic fatigue, dyspnea or exercise intolerance after COVID-19 with otherwise unclear etiology (PASC group only)

Exclusion Criteria

  • SARS-CoV-2 infection by RT-PCR or Antigen testing within the last 3 months
  • Inability to provide consent or non-English speaking
  • Pregnancy
  • Any respiratory infection in last 4 weeks
  • PFT relative contraindications
  • History of major cardiovascular, pulmonary, renal, hepatic, autoimmune or neuromuscular disease including asthma, COPD, interstitial lung disease, heart failure, pulmonary arterial hypertension, or prior pulmonary embolism
  • Active malignancy undergoing treatment or history of malignancy involving the lung

Recruiting US locations

  • Tufts Medical Center

    Boston, MA 02111

    Site contact: Bipin Malla

Study contacts (from the official record)

  • Bipin Malla · 617-636-6304 · tuftsmccorstudy@tuftsmedicalcenter.org
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Ventilatory and Perfusion Abnormalities in Individuals With… (NCT05866952) | Bored Studies