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Young Onset Parkinson's Disease Subtypes and Pathogenic Mechanisms

NYU Langone Health · with National Institute of Neurological Disorders and Stroke (NINDS) · NCT07752355

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
250
US sites recruiting
1
Study start
February 28, 2024
Record last updated
August 12, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Young Onset Parkinson's disease (YOPD) refers to a group of patients in which the disease starts earlier in life (before the age of 50 years) and has a profound impact on most of patient's life. Current knowledge regarding the mechanisms leading to development of Parkinson's disease in younger individuals is lacking, but their understanding is crucial for the successful design of therapeutic strategies and stratifying patients for clinical trials. With this research the investigators aim to clarify the contribution of relevant biological processes in patients with Young onset Parkinson's disease to help understanding disease mechanisms and biomarkers.

Conditions: Young Onset Parkinson Disease; Parkinson Disease

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

YOPD cohort

  • Male or female 18 years or older (inclusive) of any race and ethnicity
  • Diagnosis of Parkinson's disease (PD) confirmed by a movement disorder specialist and with an age of onset of less than or equal to the age of 50 years old
  • Willingness to undergo a skin punch biopsy

LOPD cohort

  • Male or female 18 years or older (inclusive) of any race and ethnicity
  • Diagnosis of PD confirmed by a movement disorder specialist and with an age of onset after the age of 50 years

Healthy Control cohort

  • Male or female 18 years or older (inclusive) of any race and ethnicity
  • Never been diagnosed with PD as reported by medical history and as assessed by study PI

Exclusion Criteria

  • Diagnosis of atypical parkinsonism (i.e. progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy) or secondary parkinsonism (i.e. normal pressure hydrocephalus, drug-induced parkinsonism).
  • Clinical history of autoimmune or chronic inflammatory disorder or exposure to chronic immunosuppressant or immunomodulatory medications.
  • Pregnancy
  • Dermatological conditions that would prevent performing skin punch biopsies

Recruiting US locations

Study contacts (from the official record)

  • Mark Belio · 646-501-4367 · Mark.Belio@nyulangone.org
  • Kelly Astudillo · Kelly.Astudillo@nyulangone.org
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Young Onset Parkinson's Disease Subtypes and Pathogenic Mechanisms (NCT07752355) | Bored Studies