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RecruitingAccepts healthy volunteersEarly Phase 1

Zinc Oxide Versus Petrolatum Following Skin Surgery

Melissa Pugliano-Mauro · NCT03561376

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
30
US sites recruiting
1
Study start
September 1, 2021
Record last updated
September 2, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Patients undergoing routine surgery in the Department of Dermatology for any indication on non-scalp skin and closed in linear fashion with scar greater than or equal to 4.5cm in length will be invited to participate in this split scar, head to head study comparing zinc oxide and petrolatum. Patients will apply respective ointments to each half of scar daily for one month and maintain a log of these activities. They will be seen at 1 week, 4 weeks, 8 weeks, and 6 months post-operatively for photographic scar assessment and to complete the patient portion of the Patient and Observer Scar Assessment Scale (POSAS), a quantitative objective assessment of scar appearance. Trained observers (board-certified dermatologists) will score the observer portion of the scale. POSAS outcomes, post-operative infections, linear density of epidermal seal will be assessed at the 1 week, 4 weeks, 8 weeks, and 6 months post-operative periods and compared between the two groups. Participants will have parking validated for all visits and upon completion of all portions of the study will receive a standardized skin care gift bag containing samples for hypoallergenic skin care products (washes, moisturizers, etc.).

Being studied: Topical zinc oxide vs. petrolatum post-surgical scars

Conditions: Surgical Incision; Surgery--Complications; Surgical Wound; Surgical Site Infection; Scar; Hypertrophic Scar

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • ≥ 18 years of age
  • Linear closure, non-scalp site
  • ≥ 4.5 cm in length (final incision/closure length)
  • End to end symmetry (surgical site is not grossly asymmetric from end to end)
  • Grossly uninfected site

Exclusion Criteria

  • ≤ 18 years
  • Visibly asymmetric linear scar
  • Grossly infected surgical site
  • History of allergy to topical zinc oxide

Recruiting US locations

  • UPMC Dermatology St. Margaret

    Pittsburgh, PA, PA 15213

    Site contact: Caroline Kettering, MD · ketteringce@upmc.edu

Study contacts (from the official record)

  • Caroline Kettering, MD · 4126474200 · ketteringce@upmc.edu
Zinc Oxide Versus Petrolatum Following Skin Surgery (NCT03561376) | Bored Studies