Location · South Dakota
Clinical trials recruiting in South Dakota
70 recruiting studies have at least one site in South Dakota; 12 accept healthy volunteers. Studies that need a specific condition are included too, so check each listing.
Want the research companies that run paid Phase 1 studies for healthy volunteers? Paid clinical trial companies in South Dakota.
70 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- Recruiting
Evaluation of a Non-Implanted Electrical Stimulation Device for Overactive Bladder (OAB)
FemPulse Corporation
- Location
- Sioux Falls, SD + 11 other US sites
- Eligibility basics
- Ages 21+ · Women only
- Recruiting
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
Endotronix, Inc.
- Location
- Sioux Falls, SD + 43 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in…
Apellis Pharmaceuticals, Inc.
- Location
- Sioux Falls, SD + 77 other US sites
- Eligibility basics
- Ages 60+
- RecruitingPhase 1
Study of BHV-1400 in IgA Nephropathy
Biohaven Therapeutics Ltd.
- Location
- Dakota Dunes, SD + 13 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 3
A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PEAK
Kodiak Sciences Inc
- Location
- Sioux Falls, SD + 47 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PINNACLE
Kodiak Sciences Inc
- Location
- Sioux Falls, SD + 47 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease
Abivax S.A.
- Location
- Rapid City, SD + 23 other US sites
- Eligibility basics
- Ages 18–75
- Recruiting
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
Cardiac Dimensions, Inc.
- Location
- Sioux Falls, SD + 50 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)
Deciphera Pharmaceuticals, LLC
- Location
- Sioux Falls, SD + 25 other US sites
- Eligibility basics
- Ages 18+
- Recruiting
Melodi Matrix™ in Breast Reconstruction
Melodi Health, Inc.
- Location
- Rapid City, SD + 9 other US sites
- Eligibility basics
- Ages 22+ · Women only
- Recruiting
Evaluating Patient Reported Outcomes and Surgeon Satisfaction With Ziplyft™
Osheru Inc.
- Location
- Sioux Falls, SD + 4 other US sites
- Eligibility basics
- Ages 35+
- RecruitingPhase 2
Trial of the Impact of Sibeprenlimab on Immunoglobulin A Nephropathy Kidney Tissue
Otsuka Pharmaceutical Development & Commercialization, Inc.
- Location
- Dakota Dunes, SD + 3 other US sites
- Eligibility basics
- Ages 16+
- RecruitingHealthy volunteers
Connect for Cancer Prevention Study (Connect)
National Cancer Institute (NCI)
- Location
- Sioux Falls, SD + 8 other US sites
- Eligibility basics
- Ages 30–70
- RecruitingHealthy volunteers
Education & Mentorship of Advanced Practice Providers to Increase Community-based Research Within the NCORP Network, COACH-APP Trial
Wake Forest University Health Sciences
- Location
- Sioux Falls, SD + 42 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 4
BL-RX01-TFSTAB-1402
Vance Thompson Vision
- Location
- Sioux Falls, SD
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 4
Efficacy of Kera Sol Tears on Signs and Symptoms of Surgical Temporary Ocular Discomfort Syndrome (STODS) in Subjects Following LASIK
Vance Thompson Vision
- Location
- Sioux Falls, SD
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Assessing the Influence of Habitual Beef Intake on Key Molecular Markers of Brain Health
South Dakota State University
- Location
- Brookings, SD
- Eligibility basics
- Ages 65+
- RecruitingHealthy volunteers
Midwest Birth Outcomes and Indigenous American Pregnancy
Sanford Health
- Location
- Sioux Falls, SD + 1 other US site
- Eligibility basics
- Ages 18+ · Women only
- RecruitingHealthy volunteers
General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery
Sanford Health
- Location
- Sioux Falls, SD + 3 other US sites
- Eligibility basics
- Up to age 17
- RecruitingHealthy volunteers
Evaluating Crosslinked Hyaluronate Canalicular Gel for the Treatment of DED in Patients Undergoing Cataract Surgery
Vance Thompson Vision
- Location
- Sioux Falls, SD
- Eligibility basics
- Ages 22+
- RecruitingHealthy volunteers
Healing Within: Mindfulness Smoking Cessation Intervention
National Heart, Lung, and Blood Institute (NHLBI)
- Location
- Rapid City, SD
- Eligibility basics
- Ages 18+ · Women only
- RecruitingHealthy volunteers
Improving Neurodevelopmental ouTcomes After Prenatal Cannabinoid in uTero Exposure
IDeA States Pediatric Clinical Trials Network
- Location
- Sioux Falls, SD + 2 other US sites
- Eligibility basics
- Up to age 0 mo