Phase 1 · Connecticut
Phase 1 clinical trials in Connecticut
50 studies have at least one recruiting site in Connecticut. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
50 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in Humans
Deepak C. D'Souza
- Location
- West Haven, CT
- Eligibility basics
- Ages 21–65
- RecruitingHealthy volunteersPhase 1
AB821 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
Saci Nivo Rela for TNBC
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study II
Yale University
- Location
- West Haven, CT
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Cannabidiol Effects on Learning and Anxiety
University of Connecticut
- Location
- Storrs, CT
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteersEarly Phase 1
Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503
University of Pennsylvania
- Location
- New Haven, CT + 2 other US sites
- Eligibility basics
- Ages 40–85
- RecruitingHealthy volunteersEarly Phase 1
SV2A Density Cannabis Use Disorder
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
Open-Label Psilocybin Study in Transdiagnostic Population
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Bone Marrow Derived Stem Cells Mobilization for Treatment of Abnormal Endometrium
Hugh Taylor
- Location
- Orange, CT
- Eligibility basics
- Ages 18–40 · Women only
- RecruitingHealthy volunteersEarly Phase 1
Intradermal Influenza Vaccination
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18–40
- RecruitingHealthy volunteersPhase 1
Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans
Yale University
- Location
- West Haven, CT
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study I
Yale University
- Location
- West Haven, CT
- Eligibility basics
- Ages 18–55
- RecruitingPhase 1/Phase 2
A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B
Regeneron Pharmaceuticals
- Location
- New Haven, CT + 16 other US sites
- Eligibility basics
- Ages 2+ · Men only
- RecruitingPhase 1/Phase 2
A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With…
Cabaletta Bio
- Location
- New Haven, CT + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated
Boehringer Ingelheim
- Location
- Waterford, CT + 24 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study to Evaluate Topical ATR04-484 for EGFRi-Associated Dermal Toxicity
Azitra Inc.
- Location
- New Haven, CT + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Gene Therapy Study of SPK-8011QQ in Adults With Severe or Moderately Severe Hemophilia A
Hoffmann-La Roche
- Location
- New Haven, CT + 5 other US sites
- Eligibility basics
- Ages 18+ · Men only
- RecruitingPhase 1/Phase 2
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
Sumitomo Pharma America, Inc.
- Location
- New Haven, CT + 29 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Study to Evaluate the Efficacy and Safety of Cannabidiol Oral Solution (CBD-OS [GWP42003-P, JZP926]) for the Treatment of Focal-Onset Seizures
Jazz Pharmaceuticals
- Location
- New Haven, CT + 20 other US sites
- Eligibility basics
- Ages 12–75
- RecruitingPhase 1/Phase 2
A First-in-human Study of KK8123 in Adults With X-linked Hypophosphatemia
Kyowa Kirin Co., Ltd.
- Location
- New Haven, CT + 3 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
Study of BHV-1400 in IgA Nephropathy
Biohaven Therapeutics Ltd.
- Location
- Farmington, CT + 13 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis
Monument Therapeutics Limited
- Location
- New Haven, CT + 14 other US sites
- Eligibility basics
- Ages 17–30
- RecruitingPhase 1/Phase 2
Study to Assess the Safety, Tolerability, and Preliminary Efficacy of ST266 in Infants With Necrotizing Enterocolitis (NEC)
Noveome Biotherapeutics, formerly Stemnion
- Location
- New Haven, CT + 7 other US sites
- Eligibility basics
- Ages 0 mo–2 mo
- RecruitingPhase 1
Study of NTX-2001 on Alcohol Consumption in Alcohol Use Disorder
Newleos Therapeutics, Inc.
- Location
- New Haven, CT
- Eligibility basics
- Ages 21–60
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.