Phase 1 · Connecticut
Phase 1 clinical trials in Connecticut
50 studies have at least one recruiting site in Connecticut. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
50 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1Overnight stay mentioned
A Study to Learn How Different Amounts of the Study Medicine Called PF-08103402 Are Tolerated and Act in the Body in Healthy Adults or Adults With Mild To-moderate Asthma
Pfizer
- Location
- New Haven, CT
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1Overnight stay mentioned
Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 21–70
- RecruitingHealthy volunteersPhase 1
MK-0947 PN-002: An Open-label Study to Evaluate Brain α-synuclein Deposition Using Positron Emission Tomography (PET) and [¹⁸F]MK-0947 in Participants With Parkinson's Disease (PD)
XingImaging, LLC
- Location
- New Haven, CT
- Eligibility basics
- Ages 40–80
- RecruitingHealthy volunteersEarly Phase 1
A Study of the Pharmacokinetics, Biodistribution and Dosimetry of Granzyme-B Targeted [Cu-64]-Labeled PET Radiotracers in Adult Healthy Volunteers
Ratio Therapeutics, Inc.
- Location
- New Haven, CT
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
A Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of BCX17725
BioCryst Pharmaceuticals
- Location
- New Haven, CT + 4 other US sites
- Eligibility basics
- Ages 12–65
- RecruitingHealthy volunteersPhase 1/Phase 2
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Bristol-Myers Squibb
- Location
- New Haven, CT + 8 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Evaluation of [¹⁸F]MODAG-009 PET Imaging in Synucleinopathies
MODAG GmbH
- Location
- New Haven, CT
- Eligibility basics
- Ages 50–80
- RecruitingHealthy volunteersEarly Phase 1
Evaluation of the Pharmacokinetics, Biodistribution and Radiation Dosimetry of [18F]MODAG-009 Positron Emission Tomography (PET) Radiotracers in Adult Healthy Volunteers
MODAG GmbH
- Location
- New Haven, CT
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1/Phase 2
A First in Human Study of CMND-100 in Healthy and Alcohol Use Disorder (AUD) Subjects
Clearmind Medicine Inc.
- Location
- New Haven, CT + 1 other US site
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
Sustained Acoustic Medicine (SAM) for Symptomatic Treatment of Pain Related to Bone Fracture
ZetrOZ, Inc.
- Location
- Trumbull, CT + 1 other US site
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1/Phase 2
SV2A in Older Adults
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 50+
- RecruitingHealthy volunteersPhase 1/Phase 2
SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During Antiretroviral Therapy
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
Membrane Potential Mapping with18F-TPP
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 21–80
- RecruitingHealthy volunteersPhase 1
Acute Effects of THC in Older Adult
Yale University
- Location
- West Haven, CT
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersPhase 1
Characterization of CB1 Receptors Using [11-C]OMAR in Opioid Use Disorder
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 25–65
- RecruitingHealthy volunteersPhase 1/Phase 2
Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Iadademstat + SBRT With Atezo in ES-SCLC
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
OMAR Opioid Use Disorder
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Exploring the Utility of [18F]3F4AP for Demyelination Imaging
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18–90
- RecruitingHealthy volunteersPhase 1
Genetic Basis of the Risk and Consequences of Cannabis Exposure in Humans
Yale University
- Location
- West Haven, CT
- Eligibility basics
- Ages 21–60
- RecruitingHealthy volunteersEarly Phase 1
Evaluation of [18F]GATT-44 for Positron Emission Tomography Imaging of the GABA Transporter-1
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females
University of Connecticut
- Location
- Storrs, CT
- Eligibility basics
- Ages 45–70 · Women only
- RecruitingHealthy volunteersEarly Phase 1
PK/PD of Oral and Vaporized Delta-9-Tetrahydrocannabinol (THC) in Older Adults
Yale University
- Location
- West Haven, CT
- Eligibility basics
- Ages 65+
- RecruitingHealthy volunteersEarly Phase 1
Mechanistic Studies of Psilocybin in Headache Disorders
Yale University
- Location
- West Haven, CT
- Eligibility basics
- Ages 21–70
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.