Phase 1 · Florida
Phase 1 clinical trials in Florida
191 studies have at least one recruiting site in Florida. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
191 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity
MBX Biosciences
- Location
- Doral, FL + 3 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
A Study of Efimosfermin Alfa in Adults With Hepatic Impairment
GlaxoSmithKline
- Location
- Tampa, FL + 2 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
SAD Study in Patients With Parkinson's Disease and Motor Fluctuations
Serina Therapeutics
- Location
- Hallandale, FL + 2 other US sites
- Eligibility basics
- Ages 40–80
- RecruitingPhase 1/Phase 2
A Phase 1/2 Study of NKX019 in Subjects With Autoimmune Disease (Ntrust-1)
Nkarta, Inc.
- Location
- Gainesville, FL + 15 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
Study of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an IPAA (PROF)
Exegi Pharma, LLC
- Location
- Jacksonville, FL + 7 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
Fate Therapeutics
- Location
- Gainesville, FL + 15 other US sites
- Eligibility basics
- Ages 12–70
- RecruitingPhase 1/Phase 2
A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Immunoglobulin Light Chain (AL) Amyloidosis Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion
AbbVie
- Location
- Miami, FL + 11 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Study Assessing KB407 for the Treatment of Cystic Fibrosis
Krystal Biotech, Inc.
- Location
- Gainesville, FL + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Phase 1, Multiple Ascending Dose Study to Evaluate HMS1005 in Participants With Type 2 Diabetes
Hua Medicine Limited
- Location
- Miami, FL
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis
Amylyx Pharmaceuticals Inc.
- Location
- Gainesville, FL + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Study to Assess the Safety, Tolerability, and Preliminary Efficacy of ST266 in Infants With Necrotizing Enterocolitis (NEC)
Noveome Biotherapeutics, formerly Stemnion
- Location
- Tampa, FL + 7 other US sites
- Eligibility basics
- Ages 0 mo–2 mo
- RecruitingPhase 1
First in Human Study in Subjects With Obesity, But Otherwise Healthy
NeuroBo Pharmaceuticals Inc.
- Location
- Miami, FL
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
A Study to Investigate the Safety, Tolerability, and Preliminary Efficacy With AION-301 Administered by Intravenous Infusion Compared With Placebo Administered by Intravenous Infusion Investigational Intervention in…
AION Healthspan, Inc.
- Location
- Miami, FL + 1 other US site
- Eligibility basics
- Ages 35–75
- RecruitingPhase 1/Phase 2
Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes
Creative Medical Technology Holdings Inc
- Location
- Miami, FL
- Eligibility basics
- Ages 18–35
- RecruitingPhase 1/Phase 2
A Phase 1b/2 Study of IM-101 in Adult Participants With Generalized Myasthenia Gravis and Ocular Myasthenia Gravis
ImmunAbs Inc.
- Location
- Altamonte Springs, FL + 3 other US sites
- Eligibility basics
- Ages 18–74
- RecruitingPhase 1/Phase 2
Study of ATX-01 in Participants With DM1
ARTHEx Biotech S.L.
- Location
- Gainesville, FL + 4 other US sites
- Eligibility basics
- Ages 18–64
- RecruitingPhase 1/Phase 2
Treatment of Moderate to Severe Refractory Crohn's Disease
Tr1X, Inc.
- Location
- Gainesville, FL + 12 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
A Study of KB408 for the Treatment of Alpha-1 Antitrypsin Deficiency
Krystal Biotech, Inc.
- Location
- Gainesville, FL + 2 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
A Phase 1/2, First-in-Human Dose Escalation/Expansion Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of a Subretinal Injection of SB-007 in Subjects With Stargardt Disease (STGD1)
Splice Bio
- Location
- Miami, FL + 4 other US sites
- Eligibility basics
- Ages 12–65
- RecruitingPhase 1
Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL
Ascentage Pharma Group Inc.
- Location
- Jacksonville, FL + 6 other US sites
- Eligibility basics
- Ages 18–85
- RecruitingPhase 1
Study to Evaluate the Safety of CG-P5 Peptide Eye Drops in Patients Diagnosed With Age-related Wet Macular Degeneration
Caregen Co. Ltd.
- Location
- Deerfield Beach, FL + 6 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 1
Study of SFA002 in Patients with Mild to Moderate Psoriasis Plaques
SFA Therapeutics
- Location
- Pompano Beach, FL + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Pharmacokinetics, Safety, Tolerability of Dolutegravir/Rilpivirine in Pediatrics
ViiV Healthcare
- Location
- Miami, FL + 5 other US sites
- Eligibility basics
- Ages 6–12
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.