Phase 1 · Philadelphia area, PA
Phase 1 clinical trials in Philadelphia area, PA
64 recruiting studies have a site in the Philadelphia area. This page includes nearby cities such as Upland, Bryn Mawr, Wynnewood, Abington.
64 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 1/Phase 2
A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)
Solid Biosciences Inc.
- Location
- Philadelphia, PA + 11 other US sites
- Eligibility basics
- Ages 0 mo–17 · Men only
- RecruitingPhase 1/Phase 2
A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis
Monument Therapeutics Limited
- Location
- Philadelphia, PA + 14 other US sites
- Eligibility basics
- Ages 17–30
- RecruitingPhase 1/Phase 2
Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP)
Recursion Pharmaceuticals Inc.
- Location
- Philadelphia, PA + 6 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
Fate Therapeutics
- Location
- Philadelphia, PA + 15 other US sites
- Eligibility basics
- Ages 12–70
- RecruitingPhase 1/Phase 2
A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease
Hoffmann-La Roche
- Location
- Philadelphia, PA + 4 other US sites
- Eligibility basics
- Ages 25–65
- RecruitingPhase 1
AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis
Amylyx Pharmaceuticals Inc.
- Location
- Philadelphia, PA + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study
ModernaTX, Inc.
- Location
- Philadelphia, PA + 5 other US sites
- Eligibility basics
- Ages 1+
- RecruitingPhase 1/Phase 2
Safety and Tolerability Subretinal OPGx-001 for LCA5-Associated Inherited Retinal Degeneration (LCA5-IRD) and Non-interventional Arm With Untreated Patients
Opus Genetics, Inc
- Location
- Philadelphia, PA + 1 other US site
- Eligibility basics
- Ages 4+
- RecruitingPhase 1/Phase 2
Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia
ModernaTX, Inc.
- Location
- Philadelphia, PA + 7 other US sites
- Eligibility basics
- Any age listed
- RecruitingPhase 1
Orbit Study: A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Intrathecally Administered ION356 in Participants With Pelizaeus Merzbacher Disease (PMD)
Ionis Pharmaceuticals, Inc.
- Location
- Philadelphia, PA + 2 other US sites
- Eligibility basics
- Ages 2–17 · Men only
- RecruitingPhase 1
A Study to Investigate the Safety, Tolerability, and Efficacy of BxC-I17e Single and Multiple Dose SC Injection in Patients With Moderate to Severe Atopic Dermatitis
Brexogen Inc.
- Location
- Camp Hill, PA + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics
PharmaIN
- Location
- Philadelphia, PA + 8 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
MSC EVs in Dystrophic Epidermolysis Bullosa
Aegle Therapeutics
- Location
- Philadelphia, PA + 2 other US sites
- Eligibility basics
- Ages 6 mo+
- RecruitingPhase 1
Study to Evaluate the Safety of CG-P5 Peptide Eye Drops in Patients Diagnosed With Age-related Wet Macular Degeneration
Caregen Co. Ltd.
- Location
- Erie, PA + 6 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 1
Study of SFA002 in Patients with Mild to Moderate Psoriasis Plaques
SFA Therapeutics
- Location
- Philadelphia, PA + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Phase 1/2 Trial of SP-101 for the Treatment of Cystic Fibrosis (CF)
Spirovant Sciences, Inc.
- Location
- Philadelphia, PA + 3 other US sites
- Eligibility basics
- Ages 18–65
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.