Phase 1 · Pittsburgh area, PA
Phase 1 clinical trials in Pittsburgh area, PA
27 recruiting studies have a site in the Pittsburgh area. This page includes nearby cities such as Monroeville, Wexford, Bethel Park, Greensburg.
27 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1Overnight stay mentioned
Intralesional 5-Fluorouracil (5FU), Topical Calcipotriene Treatment for SCC
Melissa Pugliano-Mauro
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)
Novartis Pharmaceuticals
- Location
- Pittsburgh, PA + 18 other US sites
- Eligibility basics
- Ages 18–100
- RecruitingHealthy volunteersPhase 1/Phase 2
Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)
Vega Therapeutics, Inc
- Location
- Pittsburgh, PA + 9 other US sites
- Eligibility basics
- Ages 12–60
- RecruitingHealthy volunteersPhase 1
Phase 1 Study of CH505 HIV Vaccine Nanoparticles and mRNA Boosters in Healthy Adults
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Pittsburgh, PA + 1 other US site
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Imaging Mitochondrial Complex-I in Alcohol Use Disorder
Rajesh Narendran
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Imaging Mitochondrial Complex-I in Cocaine Use Disorder: a [F-18]BCPP-EF PET Study
Rajesh Narendran
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersPhase 1
Clinical Trial to Evaluate the Safety and Immunogenicity of the V2 Apex-Directed Immunogens DV201P-RNA and DV202B1-RNA in Adult Participants Without HIV
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Philadelphia, PA + 6 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Imaging CRF X NOP Interactions in CUD
Rajesh Narendran
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Imaging CRF X NOP Interactions in Alcohol Use Disorder
Rajesh Narendran
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Ketamine and Propofol NeuroImaging
Keith M Vogt
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–59
- RecruitingHealthy volunteersEarly Phase 1
Remimazolam NeuroImaging
Keith M Vogt
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–59
- RecruitingHealthy volunteersEarly Phase 1
PET Image in PAH Patients
Stephen Y. Chan
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1
Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability up to 6 Years of Intravenous (i.v.) Secukinumab in Pediatric Participants With Juvenile Psoriatic Arthritis (JPsA).
Novartis Pharmaceuticals
- Location
- Pittsburgh, PA + 10 other US sites
- Eligibility basics
- Ages 2–17
- RecruitingPhase 1
A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077)
Merck Sharp & Dohme LLC
- Location
- Philadelphia, PA + 20 other US sites
- Eligibility basics
- Up to age 17
- RecruitingPhase 1/Phase 2
A Study to Evaluate Safety, Tolerability, and Efficacy of AB-1009 Gene Therapy (GAA Gene) in Adult Participants With Late-Onset Pompe Disease (PROGRESS-GT LOPD)
AskBio Inc
- Location
- Philadelphia, PA + 4 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)
Disc Medicine, Inc
- Location
- Pittsburgh, PA + 10 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AG-181 in Subjects With Phenylketonuria
Agios Pharmaceuticals, Inc.
- Location
- Pittsburgh, PA + 2 other US sites
- Eligibility basics
- Ages 18–69
- RecruitingPhase 1/Phase 2
Safety, PK/PD, and Exploratory Efficacy Study of AMT-191 in Classic Fabry Disease
UniQure Biopharma B.V.
- Location
- Pittsburgh, PA + 9 other US sites
- Eligibility basics
- Ages 18–65 · Men only
- RecruitingPhase 1/Phase 2
Study of CTO1681 for the Prevention and Treatment of CRS in Patients Receiving CAR T-Cell Therapy
CytoAgents, Inc.
- Location
- Pittsburgh, PA + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
UniQure Biopharma B.V.
- Location
- Philadelphia, PA + 15 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
AAV Gene Therapy Clinical Study in Adult Classic PKU (PHEdom)
NGGT INC.
- Location
- Pittsburgh, PA + 4 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingPhase 1
A Study of CDX-622 in Participants With Mild to Moderate Asthma
Celldex Therapeutics
- Location
- Pittsburgh, PA + 3 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis
Monument Therapeutics Limited
- Location
- Philadelphia, PA + 14 other US sites
- Eligibility basics
- Ages 17–30
- RecruitingPhase 1/Phase 2
A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease
Hoffmann-La Roche
- Location
- Philadelphia, PA + 4 other US sites
- Eligibility basics
- Ages 25–65
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.