Phase 1 · Philadelphia area, PA
Phase 1 clinical trials in Philadelphia area, PA
64 recruiting studies have a site in the Philadelphia area. This page includes nearby cities such as Upland, Bryn Mawr, Wynnewood, Abington.
64 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1/Phase 2
A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
Novartis Pharmaceuticals
- Location
- Philadelphia, PA + 7 other US sites
- Eligibility basics
- Ages 12–55
- RecruitingHealthy volunteersPhase 1/Phase 2
Phase 1/2 Study of Respiratory Syncytial Virus and Human Metapneumovirus (RSV+HMPV) Vaccine Candidate in Adults 60 Years of Age and Older
Sanofi
- Location
- Philadelphia, PA + 49 other US sites
- Eligibility basics
- Ages 60+
- RecruitingHealthy volunteersPhase 1
A Research Study Looking at How Different Doses of Study Medicine (Inno8) Work in the Body of People With Haemophilia A
Novo Nordisk A/S
- Location
- Hershey, PA + 4 other US sites
- Eligibility basics
- Ages 18–64 · Men only
- RecruitingHealthy volunteersPhase 1/Phase 2
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Bristol-Myers Squibb
- Location
- Philadelphia, PA + 8 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
FIH Study to Evaluate the Tolerability of PF-07832837 in Healthy Adults and Patients
Pfizer
- Location
- Philadelphia, PA + 4 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersPhase 1
A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B or Factor VII…
Equilibra Bioscience LLC
- Location
- Hershey, PA + 6 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
A 3-part Study of SYX-5219 in Healthy Volunteers and Participants With Atopic Dermatitis
Sitryx Therapeutics Ltd
- Location
- Philadelphia, PA + 5 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2Overnight stay mentioned
Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS
Vector Y Therapeutics
- Location
- Philadelphia, PA + 3 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Army-SPRING Army-Suicide Prevention Research
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Any age listed
- RecruitingHealthy volunteersPhase 1/Phase 2
Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic Malignancies
National Cancer Institute (NCI)
- Location
- Philadelphia, PA + 1 other US site
- Eligibility basics
- Ages 12–85
- RecruitingHealthy volunteersPhase 1
Validation of Nanosensor Oxygen Measurement
Children's Hospital of Philadelphia
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersPhase 1
Clinical Trial to Evaluate the Safety and Immunogenicity of Hiltonol, Poly-ICLC-adjuvanted CD40.HIVRI.Env (VRIPRO) in Adult Participants Who Previously Participated in HVTN 706
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Philadelphia, PA + 3 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
A Study of Safety and Drug Levels of ePGT121v1-LS, PGDM1400LS, and VRC07-523LS in Adult Participants Without HIV-1
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Philadelphia, PA + 4 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Neoadjuvant Pembrolizumab and Lenvatinib for Renal Cell Carcinoma
Abramson Cancer Center at Penn Medicine
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Clinical Trial to Evaluate the Safety and Immunogenicity of the V2 Apex-Directed Immunogens DV201P-RNA and DV202B1-RNA in Adult Participants Without HIV
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Philadelphia, PA + 6 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
18F-FTHA IMAGING OF THE INTESTINAL AND CENTRAL LYMPHATIC SYSTEM
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503
University of Pennsylvania
- Location
- Philadelphia, PA + 2 other US sites
- Eligibility basics
- Ages 40–85
- RecruitingHealthy volunteersPhase 1
Validation of Oxygen Nanosensor in Mitochondrial Myopathy
Children's Hospital of Philadelphia
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Localizing Epileptic Networks Using MRI and iEEG
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Study of Biodistribution, Metabolism, Excretion and Brain Uptake of 11C-HY-2-15
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 40–80
- RecruitingHealthy volunteersPhase 1
Applying pGz in Mitochondrial Disease
Children's Hospital of Philadelphia
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 10–60
- RecruitingHealthy volunteersPhase 1/Phase 2
Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B
Regeneron Pharmaceuticals
- Location
- Philadelphia, PA + 16 other US sites
- Eligibility basics
- Ages 2+ · Men only
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.