Phase 1 · Nashville area, TN
Phase 1 clinical trials in Nashville area, TN
25 recruiting studies have a site in the Nashville area. This page includes nearby cities such as Franklin, Brentwood, Murfreesboro, Hermitage.
25 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1/Phase 2
Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)
Vega Therapeutics, Inc
- Location
- Nashville, TN + 9 other US sites
- Eligibility basics
- Ages 12–60
- RecruitingHealthy volunteersPhase 1
Clinical Trial to Evaluate the Safety and Immunogenicity of Hiltonol, Poly-ICLC-adjuvanted CD40.HIVRI.Env (VRIPRO) in Adult Participants Who Previously Participated in HVTN 706
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Nashville, TN + 3 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
A Study of Safety and Drug Levels of ePGT121v1-LS, PGDM1400LS, and VRC07-523LS in Adult Participants Without HIV-1
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Nashville, TN + 4 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Attentional Mechanisms in SCD
Vanderbilt University Medical Center
- Location
- Nashville, TN
- Eligibility basics
- Ages 55+
- RecruitingHealthy volunteersPhase 1/Phase 2
Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans
Vanderbilt University Medical Center
- Location
- Nashville, TN
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
Tranexamic Acid in Rhinoplasty: Perioperative Bleeding, Edema and Ecchymosis
Vanderbilt University Medical Center
- Location
- Nashville, TN
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
[18F]F-DOPA Imaging in Patients With Autonomic Failure
Daniel Claassen
- Location
- Nashville, TN
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 Diabetes
Vanderbilt University Medical Center
- Location
- Nashville, TN
- Eligibility basics
- Ages 18–60
- RecruitingPhase 1/Phase 2
A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B
Regeneron Pharmaceuticals
- Location
- Nashville, TN + 16 other US sites
- Eligibility basics
- Ages 2+ · Men only
- RecruitingPhase 1
Safety and Efficacy of Soquelitinib in Adults With Hidradenitis Suppurativa
Corvus Pharmaceuticals, Inc.
- Location
- Nashville, TN + 8 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated
Boehringer Ingelheim
- Location
- Nashville, TN + 24 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)
Ionis Pharmaceuticals, Inc.
- Location
- Nashville, TN + 7 other US sites
- Eligibility basics
- Ages 2–65 · Men only
- RecruitingPhase 1/Phase 2
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
Sumitomo Pharma America, Inc.
- Location
- Nashville, TN + 29 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A First-in-human Study of KK8123 in Adults With X-linked Hypophosphatemia
Kyowa Kirin Co., Ltd.
- Location
- Nashville, TN + 3 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
A Study to Evaluate Sequential Administration of Injections of AGN-151586 Followed by BOTOX in Adult Participants for Treatment of Glabellar Lines
AbbVie
- Location
- Nashville, TN + 7 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)
Locate Bio Pty Ltd
- Location
- Nashville, TN + 2 other US sites
- Eligibility basics
- Ages 22–80
- RecruitingPhase 1/Phase 2
4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration
4D Molecular Therapeutics
- Location
- Nashville, TN + 19 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 1/Phase 2
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne
Sanofi Pasteur, a Sanofi Company
- Location
- Smyrna, TN + 78 other US sites
- Eligibility basics
- Ages 18–45
- RecruitingPhase 1/Phase 2
A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)
AviadoBio Ltd
- Location
- Nashville, TN + 2 other US sites
- Eligibility basics
- Ages 30–75
- RecruitingPhase 1
A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults
UCB Biopharma SRL
- Location
- Jackson, TN + 29 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.
Alexion Pharmaceuticals, Inc.
- Location
- Nashville, TN + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingEarly Phase 1
VTP-1000 in Adults With Celiac Disease
Barinthus Biotherapeutics
- Location
- Nashville, TN + 15 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP)
Recursion Pharmaceuticals Inc.
- Location
- Nashville, TN + 6 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Immunoglobulin Light Chain (AL) Amyloidosis Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion
AbbVie
- Location
- Nashville, TN + 11 other US sites
- Eligibility basics
- Ages 18+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.