A Study of MZE782 in Adults With PKU
Maze Therapeutics · NCT07694440
Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.
Key facts
- Compensation
- Not posted. Ask the study team before screening.
- Who can join
- Ages 18–75 · All sexes
- Healthy volunteers
- Not accepted (a condition is required)
- Study type
- Interventional · Phase 2
- Target enrollment
- 38
- US sites recruiting
- 7
- Study start
- June 23, 2026
- Record last updated
- October 23, 2026
Status re-checked against ClinicalTrials.gov within the last 12 hours.
What the study is about
The purpose of this study is to evaluate the safety, tolerability, and efficacy of MZE782 in adults with Phenylketonuria (PKU).
Being studied: MZE782; Placebo; MZE782
Conditions: Phenylketonuria (PKU)
Eligibility criteria
Copied from the official record. The study team makes the final decision at screening.
Show full criteria
Key Inclusion Criteria
- Males and females 18 to 75 years old
- Confirmed diagnosis of PKU
- Willing and able to keep diet and protein intake consistent during the study
- For some study groups, is willing and able to stop certain PKU medications before starting study treatment
- For some study groups, may need to meet additional blood phenylalanine level or background-treatment requirements
- Meets minimum blood phenylalanine level requirements for study group
Key Exclusion Criteria
- Is pregnant, breastfeeding, or planning to become pregnant or conceive a child during the study
- Medical conditions or abnormal test results that could make participation unsafe or make it difficult to complete study procedures or interpret study results
- Has recently received another investigational drug
- Is unable to swallow tablets or tolerate oral medication
Other inclusion/exclusion criteria defined in protocol apply.
Recruiting US locations
UCSF Benioff Children's Hospital Oakland
Oakland, CA 94609
Stanford University Clinical and Translational Research Unit
Palo Alto, CA 94304
Ann and Robert H. Lurie Children's Hospital of Chicago
Chicago, IL 60611
Indiana University School of Medicine
Indianapolis, IN 46202
University of Kentucky Medical Center
Lexington, KY 40536
Clinic for Special Children
Gordonville, PA 17529
University of Tennessee Health Science Center Le Bonheur Children's Hospital
Memphis, TN 38103
Study contacts (from the official record)
- Maze Therapeutics · 650-850-5075 · medicalinfo@mazetx.com