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RecruitingPhase 2

A Study to Assess the Efficacy and Safety of RO7965032 in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Genentech, Inc. · NCT07851259

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 50+ · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 2
Target enrollment
321
US sites recruiting
5
Study start
January 8, 2027
Record last updated
October 26, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study will assess the safety and efficacy of RO7965032 to address a significant unmet medical need in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD)

Being studied: RO7965032; Placebo

Conditions: Geographic Atrophy Secondary to Age-Related Macular Degeneration

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Ocular Inclusion Criteria for the Study Eye

  • BCVA score of >= 35 letters using the ETDRS VA chart at a starting distance of 4 meters
  • Lesions may be either extrafoveal or subfoveal

Ocular Inclusion Criteria for Both Eyes

  • Sufficiently clear ocular media, adequate pupillary dilation, and fixation to permit quality fundus imaging
  • Well-demarcated GA secondary to AMD

Exclusion Criteria

General Exclusion Criteria - History of hypersensitivity, a severe allergic reaction or anaphylactic reaction to any component of the investigational drug injection

Ocular Exclusion Criteria for the Study Eye

  • History of diabetic macular edema (DME), retinal vein occlusion, corneal transplant, retinal detachment, Stage 3 or 4 macular hole, optic neuropathy, or retinal dystrophy
  • Current or prior history of central serous retinopathy
  • Aphakia or absence of the posterior capsule in the study eye

Ocular Exclusion Criteria for the Non-Study Eye

  • Non-functioning non-study eye defined as either BCVA of hand motion or worse or no physical presence of non-study eye (i.e., monocular)

Ocular Exclusion Criteria for Either Eye

  • Proliferative diabetic retinopathy
  • History of recurrent infectious or inflammatory ocular disease
  • Current or prior history of choroidal neovascularization (CNV) in either eye
  • Active, infectious conjunctivitis, keratitis, scleritis, or endophthalmitis in either eye

Other protocol-defined inclusion/exclusion criteria may apply

Recruiting US locations

Study contacts (from the official record)

  • Reference Study ID Number: XR46785 https://forpatients.roche.com/No attachments to email below. · 888-662-6728 (U.S. and Canada) · global-roche-genentech-trials@gene.com
  • Fastest Response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry
A Study to Assess the Efficacy and Safety of RO7965032 in… (NCT07851259) | Bored Studies