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RecruitingPhase 2

A Study to Assess the Safety, Tolerability and Efficacy of ION775

Ionis Pharmaceuticals, Inc. · NCT07604974

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 2
Target enrollment
72
US sites recruiting
16
Study start
May 12, 2026
Record last updated
October 19, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The main objective of this study is to evaluate the effect of ION775 on fasting triglyceride (TG) levels in participants with hypertriglyceridemia (HTG) and severe hypertriglyceridemia (sHTG).

Being studied: ION775

Conditions: Hypertriglyceridemia; Severe Hypertriglyceridemia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Key Inclusion Criteria

  • Adult males and females with HTG (fasting TG more than or equal to (≥) 350 milligrams per deciliter (mg/dL) [3.95 millimoles per liter (mmol/L)] or with sHTG (fasting TG ≥ 500 mg/dL [5.65 mmol/L]).
  • Participants should be on standard of care lipid-lowering medications per local guidelines.

Key Exclusion Criteria

  • Hemoglobin A1c (HbA1c) ≥ 8.5% at Screening.
  • Alanine aminotransferase or aspartate aminotransferase > 2.0 × upper limit of normal.
  • Total bilirubin > 1.5 upper limit of normal unless due to Gilbert's syndrome.
  • Estimated GFR \< 30 mL/min/1.73 m\^2.

Note: Other protocol pre-specified inclusion/exclusion criteria may apply.

Recruiting US locations

Study contacts (from the official record)

  • Ionis Pharmaceuticals, Inc. · 1-844-828-3770 · IonisION775-CS2@clinicaltrialmedia.com
A Study to Assess the Safety, Tolerability and Efficacy of ION775 (NCT07604974) | Bored Studies