A Study to Evaluate Effect of AZD6234 as an Adjunct to Incretin-based Therapies in Adult Participants With Obesity or Overweight With Weight-related Comorbidity With or Without Type 2 Diabetes Mellitus

Inclusion Criteria

• Males \& females (inclusive of all gender identities) age ≥18 years
• BMI ≥ 30 kg/m2 OR BMI ≥ 27 kg/m2 with at least one of the following weight-related comorbidities (treated or untreated): hypertension, dyslipidaemia, obstructive sleep apnoea, cardiovascular disease, heart failure, chronic kidney disease, metabolic dysfunction associated steatotic liver disease, osteoarthritis of the knee, or stress urinary incontinence
• For participants with T2DM only:

• Diagnosed with T2DM ≥ 90 days prior to Screening
• HbA1c value at Screening of ≥6.0% (42 mmol/mol) and ≤9.0% (75 mmol/mol) managed with diet and exercise alone or with a stable dose of any oral glycaemic-lowering agent and/or incretin-based medication
• Receiving a stable dose of incretin- based medications at a dose level that is sufficient for chronic weight management for at least 3 months prior to Screening and Randomisation.
• Stable body weight (≤ 3% body weight change) for at least 3 months prior to Randomisation
• History of at least one self-reported unsuccessful attempt to lose body weight in their lifetime

Exclusion Criteria

• Obesity primarily caused by other endocrine disorders
• Type 1 diabetes mellitus
• Significant hepatobiliary disease and/or any of the following results at Screening:

• ALT ≥ 3.0 × ULN
• AST ≥ 3.0 × ULN
• TBL > 1.5 × ULN (except for cases of known Gilbert's Syndrome)
• Use of insulin therapy for T2DM within 3 months prior to screening