A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
Genentech, Inc. · NCT06979336
Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.
Key facts
- Compensation
- Not posted. Ask the study team before screening.
- Who can join
- Ages 18+ · All sexes
- Healthy volunteers
- Not accepted (a condition is required)
- Study type
- Interventional · Phase 2
- Target enrollment
- 224
- US sites recruiting
- 8
- Study start
- September 29, 2025
- Record last updated
- September 28, 2026
Status re-checked against ClinicalTrials.gov within the last 12 hours.
What the study is about
The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis for whom prior treatment with conventional and/or advanced therapies has failed.
Being studied: RO7837195; RO7837195 Matched Placebo
Conditions: Ulcerative Colitis
Eligibility criteria
Copied from the official record. The study team makes the final decision at screening.
Show full criteria
Inclusion Criteria
- Diagnosis of ulcerative colitis (UC) established at least 3 months
- Moderately to severely active UC assessed by mMS
- Inadequate response, loss of response, or intolerance to conventional or advanced therapies for UC
Exclusion Criteria
- Prior extensive colonic resection, subtotal or total colectomy, or planned surgery for UC
- Diagnosis of Crohn's disease or indeterminate colitis
- Treatment with an advanced therapy targeted at tumor necrosis factor-like cytokine 1A (TL1a)
- Inadequate response, loss of response, or intolerance to treatment of UC with an advanced therapy targeted at IL-12 and/or IL-23
Recruiting US locations
Gastro Care Institute
Lancaster, CA 93534
Medical Associates Research Group, Inc.
San Diego, CA 92123
Peak Gastroenterology Associates
Colorado Springs, CO 80907
Clinical Research of Osceola, LLC
Kissimmee, FL 34741
University of Chicago Medical Center
Chicago, IL 60637
Intercity Gastroenterology
Fresh Meadows, NY 11366
Monroe Biomedical Research
Monroe, NC 28112
University of Utah Hospitals & Clinics
Salt Lake City, UT 84132
Study contacts (from the official record)
- Reference Study ID Number: GA45977 https://forpatients.roche.com/ No attachments to email below. · 888-662-6728 (U.S.) · global-roche-genentech-trials@gene.com
- Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry