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RecruitingPhase 3

Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)

Eli Lilly and Company · NCT07157774

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 3
Target enrollment
10450
US sites recruiting
121
Study start
September 2, 2025
Record last updated
September 24, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke.

Being studied: Muvalaplin; Placebo

Conditions: Elevated Lp(a); Atherosclerotic Cardiovascular Disease (ASCVD)

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Have Lp(a) ≥175 nanomoles per liter (nmol/L)
  • Meet one of the following criteria:
  • Have had a prior atherosclerotic cardiovascular disease (ASCVD) event (such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body) within 10 years prior to screening
  • Are at risk for a first ASCVD event, defined as one or more of the following:
  • Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without a history of ASCVD event
  • A high coronary artery calcium (CAC) score
  • Reduced kidney function with diabetes
  • Combination(s) of high risk factors

Exclusion Criteria

  • Have experienced a major cardiovascular event or surgery, such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body, within 90 days prior to screening or occurring between screening and randomization
  • Are planning or expected to undergo a procedure to restore blood flow in the arteries or a major heart surgery during the study
  • Have uncontrolled high blood pressure
  • Have New York Heart Association (NYHA) class III or IV heart failure
  • Have undergone a procedure to remove cholesterol from the blood within 90 days of screening, or have a planned procedure during the study
  • Have severe kidney impairment
  • Have had cancer within 5 years prior to screening

Recruiting US locations

  • Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC

    Gilbert, AZ 85296

    Site contact: 480-691-2213

  • Onyx Clinical Research

    Phoenix, AZ 85014

    Site contact: 602-830-3794

  • Clinical Research Institute of Arizona (CRI) - Sun City West

    Sun City West, AZ 85375

    Site contact: 623-293-1360

  • Southwest Kidney Institute - Surprise

    Surprise, AZ 85374

    Site contact: 480-610-6100

  • Pima Heart

    Tucson, AZ 85741

    Site contact: 5203149254 ex 13563

  • Eclipse Clinical Research

    Tucson, AZ 85745

    Site contact: 520-647-9926

  • National Heart Institute

    Beverly Hills, CA 90211

    Site contact: 310-289-9955

  • John Muir Medical Center - Concord Campus

    Concord, CA 94520

    Site contact: 925-674-2580

  • Neighborhood Healthcare Institute of Health

    Escondido, CA 92025

    Site contact: 760-737-6984

  • Ark Clinical Research - Fountain Valley

    Fountain Valley, CA 92708

    Site contact: 714-988-2021

  • Care Access - Huntington Beach

    Huntington Beach, CA 92648

    Site contact: 714-378-2440

  • The Cardiovascular Center

    Redding, CA 96001

    Site contact: 281-944-3610

  • UCLA South Bay Endocrinology

    Torrance, CA 90505

    Site contact: Dianne Cheung

  • University of Colorado Anschutz Medical Campus

    Aurora, CO 80045

    Site contact: 303-724-4651

  • Legacy Clinical Trials

    Colorado Springs, CO 80909

    Site contact: 719-387-7572

  • Cardiology Associates of Fairfield County, P.C.

    Stamford, CT 06905

    Site contact: 203-353-1133

  • Chase Medical Research, LLC

    Waterbury, CT 06708

    Site contact: 203-437-6856

  • Excel Medical Clinical Trials

    Boca Raton, FL 33434

    Site contact: 305-631-6704

  • American Research Institute

    Cutler Bay, FL 33157

    Site contact: Manuel Garcia Estrada

  • K2 Medical Research - Daytona Beach

    Daytona Beach, FL 32114

    Site contact: Joshua Eisenhut

  • Arrow Clinical Trials

    Daytona Beach, FL 32117

    Site contact: 386-278-8000

  • Soffer Health Institute

    Hollywood, FL 33020

    Site contact: Ariel Soffer

  • Jacksonville Center for Clinical Research

    Jacksonville, FL 32216

    Site contact: 904-730-0101

  • K2 MEDICAL Research THE VILLAGES

    Lady Lake, FL 32159

    Site contact: 352-500-5252

  • K2 Medical Research - Maitland

    Maitland, FL 32751

    Site contact: 407-810-2790

  • K2 Medical Research ORLANDO

    Maitland, FL 32751

    Site contact: 407-500-5252

  • Dade Florida Clinical Research Center

    Miami, FL 33173

    Site contact: 786-409-6842

  • Onhealth Research Center

    Miami, FL 33186

    Site contact: Jimena Blandon

  • Advanced Research for Health Improvement, LLC

    Naples, FL 34102

    Site contact: 239-230-2021

  • Renstar Medical Research

    Ocala, FL 34471

    Site contact: 352-629-5800

  • Care Access - Tamarac

    Tamarac, FL 33321

    Site contact: 877-791-0656

  • Care Access - Tampa

    Tampa, FL 33625

    Site contact: 813-771-5980

  • Southeastern Clinical Research Institute

    Augusta, GA 30904

    Site contact: 706-922-3005

  • Masters of Clinical Research

    Augusta, GA 30909

    Site contact: Kashif Naseem

  • Center for Advanced Research & Education

    Gainesville, GA 30501

    Site contact: 770-534-5154

  • North Georgia Clinical Research

    Woodstock, GA 30189

    Site contact: 678-494-5735

  • Elite Clinical Trials

    Blackfoot, ID 83221

    Site contact: 208-643-0006

  • High Desert Heart & Vascular

    Meridian, ID 83642

    Site contact: 208-398-4306

  • Elite Clinical Trials

    Rexburg, ID 83440

    Site contact: 208-356-8977

  • Great Lakes Clinical Trials - Ravenswood

    Chicago, IL 60640

    Site contact: 773-275-3500

  • Clinical Investigation Specialists

    Gurnee, IL 60031

    Site contact: 262-925-1280

  • AMR Clinical

    Niles, IL 60714

    Site contact: Saifullah Nasir

  • IU Health Bloomington

    Bloomington, IN 47408

    Site contact: Julie Clary

  • Indiana University Health Methodist Hospital

    Indianapolis, IN 46202

    Site contact: Julie Clary

  • Tulane University School of Medicine

    New Orleans, LA 70112

    Site contact: 504-756-5621

  • MaineHealth Cardiology

    Scarborough, ME 04074

    Site contact: Edward Teufel

  • Ascension Saint Agnes Heart Care

    Baltimore, MD 21229

    Site contact: 443-798-2670

  • Metropolitan Cardiovascular Consultants

    Beltsville, MD 20750

    Site contact: 301-595-0356

  • Flourish Research - Bowie

    Bowie, MD 20715

    Site contact: 410-824-1342

  • Johns Hopkins University

    Columbia, MD 21044

    Site contact: Daniel Kim

  • Centennial Medical Group

    Columbia, MD 21045

    Site contact: 410-730-3399

  • Anderson Medical Research

    Ft. Washington, MD 20744

    Site contact: 301-542-6741

  • Brigham and Women's Hospital Diabetes Program

    Boston, MA 02115

    Site contact: 617-732-4245

  • Lucida Clinical Trials

    New Bedford, MA 02740

    Site contact: Maria Rumsey

  • Care Access - Quincy

    Quincy, MA 02169

    Site contact: 877-791-0656

  • Revival Research Institute, LLC

    Dearborn, MI 48126

    Site contact: Qaiser Shafiq

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    Troy, MI 48098

    Site contact: 248-312-0025

  • Boeson Research MSO

    Missoula, MT 59804

    Site contact: 406-763-8833

  • Clinical Research of South Nevada

    Las Vegas, NV 89121

    Site contact: 702-570-6107

  • Vector Clinical Trials

    Las Vegas, NV 89128

    Site contact: 702-750-000

+ 61 more on the official record.

Study contacts (from the official record)

  • Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or · 1-317-615-4559 · LillyTrials@Lilly.com
  • Physicians interested in becoming principal investigators please contact · clinical_inquiry_hub@lilly.com
All heart & blood pressure studies in Arizona →
Assessing the Impact of Muvalaplin on Major Cardiovascular Events… (NCT07157774) | Bored Studies