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At Home Ammonia Monitoring of Inborn Errors of Ammonia Metabolism

Sequitur Health Corp. · with Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Oregon Health and Science University · NCT06953505

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 12+ · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Not applicable
Target enrollment
30
US sites recruiting
1
Study start
September 23, 2025
Record last updated
May 27, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this observational study is to learn if people with certain ammonia metabolism disorders will measure their ammonia levels at home.

The main question it aims to answer is

  • Will participants measure their ammonia every day?

Participants will be asked to

  • Attend two in-person study visits at the clinic.
  • Measure temperature, heart rate, and blood oxygen every day.
  • Complete a short survey every day.
  • Measure ammonia every day.

Being studied: Ammonia Study Device

Conditions: Urea Cycle Disorders; Organic Acidemias; Fatty Acid Oxidation Disorder; Ammonia; Metabolic Disorder

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Confirmed ammonia disorder such as
  • Ornithine transcarbamylase deficiency
  • Systemic primary carnitine deficiency
  • Type I citrullinemia
  • Argininosuccinic aciduria
  • Isolated methylmalonic acidemia
  • Type II citrullinemia
  • Propionic acidemia
  • Isovaleric acidemia
  • Multiple acyl-CoA dehydrogenase deficiency
  • Pyruvate carboxylase deficiency
  • Argininemia (arginase deficiency)
  • Carbamoyl phosphate synthase I deficiency
  • Dihydrolipoamide dehydrogenase deficiency
  • Lysinuric protein intolerance
  • Hyperornithinemia-hyperammonemia-homocitrullinuria
  • Carnitine-acylcarnitine translocase deficiency
  • Carbonic anhydrase VA deficiency
  • N-acetyl glutamate synthetase deficiency
  • English Literacy

Exclusion Criteria

  • Incarcerated
  • Presence of a non-inborn error of metabolism medical condition associated with abnormal ammonia metabolism (e.g., end stage liver disease).
  • Unable to read in English

Recruiting US locations

  • Oregon Health & Science University

    Portland, OR 97239-3098

    Site contact: Amy C. Yang, M.D. · 503-494-8307

Study contacts (from the official record)

  • Marylaura Thomas, Ph.D. · 1-855-445-3889 · info@sequiturhealth.com
All nutrition & metabolism studies in Oregon →
At Home Ammonia Monitoring of Inborn Errors of Ammonia Metabolism (NCT06953505) | Bored Studies