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Investigating the Bioavailability of Broccoli Extract Supplements

Oregon State University · NCT07564674

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–60 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
12
US sites recruiting
1
Study start
August 4, 2026
Record last updated
August 7, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to compare how much glucoraphanin and sulforaphane from 3 different versions of broccoli extract supplements is absorbed into the body and excreted in urine. This study involves generally healthy adults age 18-60 years. The supplements contain glucoraphanin and myrosinase enzyme, both naturally occurring in cruciferous vegetables. Once ingested, glucoraphanin is converted to the bioactive compound sulforaphane, which is thought to have numerous health benefits, including cancer prevention.

Participants will

  • consume 3 different versions of broccoli extract supplements (glucoraphanin will range from 35-70 mg)
  • complete 3 separate 24 hour study cycles
  • submit blood and urine samples for 24 hours
  • follow diet restrictions (no cruciferous vegetables or condiments or phytochemical/herbal supplements for 1 week prior to and during each study cycle)

Being studied: Avmacol Extra Strength with coating - 1 tablet; Avmacol chewable wafer - 2 tablets; Avmacol Extra Strength with coating - 2 tablets

Conditions: Diet, Healthy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Healthy adults, 18-60 years of age
  • Willing to stop taking herbal and phytochemical (plant-based extract or phytochemical) supplements for 1 week prior to and during each study cycle
  • Willing to stop cruciferous vegetable intake 1 week prior to and during each study cycle
  • Must be able to give written informed consent

Exclusion Criteria

  • Body Mass Index (BMI) \<18.5 or >30.0 kg/m2
  • Tobacco use, including e-cigarettes, or smoking of any substance (e.g. cannabis) in the past three months
  • Pregnancy, breastfeeding, or planning to become pregnant before completing the study
  • Engaging in vigorous exercise more than 7 hours per week
  • Have a significant acute or chronic illness such as cardiovascular disease, kidney or liver disease, diabetes, thyroid disorder, or radiation or chemotherapy treatment for cancer within the past five years
  • Use of medications to control cholesterol (e.g. statins, cholestyramine) or fat absorption (e.g. orlistat)
  • Have had bariatric surgery (e.g. gastric bypass, gastric banding, sleeve gastrectomy, etc.), other gastrointestinal procedure (e.g. cholecystectomy) or disorders (e.g. Crohn's disease, celiac disease, ulcerative colitis)
  • Allergic to broccoli, moringa, mustard, or maitake mushrooms
  • Weighs less than 110 pounds
  • Diagnosis of sickle cell disease

Recruiting US locations

  • Oregon State University

    Corvallis, OR 97331

    Site contact: Sandra Uesugi, RN, BSN, MS · 541-737-3594 · sandra.uesugi@oregonstate.edu

Study contacts (from the official record)

  • Emily Ho, PhD · 541-737-9559 · emily.ho@oregonstate.edu
  • Sandra Uesugi, RN, BSN, MS · 541-737-3594 · sandra.uesugi@oregonstate.edu
All nutrition & metabolism studies in Oregon →
Investigating the Bioavailability of Broccoli Extract Supplements (NCT07564674) | Bored Studies