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Dominantly Inherited Alzheimer Network (DIAN)

Washington University School of Medicine · with National Institute on Aging (NIA) · NCT00869817

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
700
US sites recruiting
7
Study start
January 2009
Record last updated
October 5, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

Conditions: Alzheimer's Disease

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Written informed consent obtained from participant and collateral source prior to any study-related procedures.
  • Aged 18 (inclusive) or older and the child of an affected individual (clinically or by testing) in a pedigree with a known mutation for ADAD.
  • Cognitively normal to very mild or mild cognitive impairment (CDR score range 0-1.0). Primary enrollment will focus on the recruitment of asymptomatic adult children who are more than 15 years younger than the estimated age of symptom onset. Enrollment of new participants with moderate cognitive impairment is allowed with the prior approval of the DIAN Coordinating Center.
  • Has two persons who are not their full-blooded siblings who can serve as collateral sources for the study.
  • Fluent in a language approved by the DIAN Coordinating Center at about the 6th grade level (international equivalent) or above.

Exclusion Criteria

  • Under age 18
  • Medical or psychiatric illness that would interfere in completing initial and follow-up visits
  • Requires nursing home level care
  • Has no one who can serve as a study informant

Recruiting US locations

  • Mayo Clinic Jacksonville

    Jacksonville, FL 32224

    Site contact: Ercilia Moncayo · Moncayo.Ercilia@mayo.edu

  • Indiana University-Indiana Alzheimer Disease Center

    Indianapolis, IN 46202

    Site contact: Jill Buck, RN · 317-963-1847 · jilmbuck@iu.edu

  • Brigham and Women's Hospital

    Boston, MA 02115

    Site contact: Alexa Coussoule · acoussoule@bwh.harvard.edu

  • Washington University in St. Louis School of Medicine

    St Louis, MO 63108

    Site contact: McCrae Johnson, RN, MSN · mccrae@wustl.edu

  • University of Pittsburgh

    Pittsburgh, PA 15260

    Site contact: Zana Ikonomovic, MD · 412-692-2740 · ikonomovics@upmc.edu

  • Butler Hospital

    Providence, RI 02906

    Site contact: Courtney Bodge, PhD · (401) 455-6403 · cbodge@butler.org

  • University of Washington

    Seattle, WA 98195

    Site contact: Sarah Taylor · saraht73@uw.edu

Study contacts (from the official record)

  • Alisha Daniels, MD,MHA · (314) 273-9057
  • DIAN Obs Admin Core · NEURO-DIANCoordinatingCenter@email.wustl.edu
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Dominantly Inherited Alzheimer Network (DIAN) (NCT00869817) | Bored Studies