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Effects of Flavonoid Foods on Carbonyl Stress

North Carolina Agriculture & Technical State University · with National Institutes of Health (NIH) · NCT07767149

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 25–70 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
36
US sites recruiting
1
Study start
September 2, 2026
Record last updated
August 24, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This randomized crossover study will compare low- and high-flavonoid diets in healthy adults to identify flavonoid-derived biomarkers in urine and plasma. Using targeted liquid chromatography-mass spectrometry (LC-MS) metabolomics, researchers will measure known and novel flavonoid metabolites and evaluate whether a higher flavonoid intake reduces carbonyl stress markers, including reactive carbonyl species (RCS) and advanced glycation end products (AGEs).

Being studied: High-Flavonoid Diet; Low-Flavonoid Diet

Conditions: Human Health; Flavonoids; Carbonyl Stress

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age 25-70 years
  • BMI between 18 and 30
  • Have no known allergy to test food
  • Have no known allergies to green tea, apples, blueberries, soy milk, or pineapples
  • Be not engaging in high-intensity exercise
  • Having blood and urine clinical tests in the normal range.
  • Be not taking antibiotics for six months
  • Be not currently taking medication
  • No taking any prescription drugs
  • All flavonoid-enriched supplements should be avoided. The flavonoid-enriched supplements list includes soy isoflavones, Lipo-Flavonoid, Citrus Bioflavonoids Complex, Super Flavonoids, Super Antioxidants, Quercetin Supplement, Essential-C, flavonoids, and milk thistle. Also other flavonoid supplements, including but not limited to luteolin, Rutin, etc.
  • No drugs or supplements within three weeks of the experiment
  • Be nonsmoking
  • Have no alcoholic intoxication
  • No alcoholic addiction
  • \< 3-4 drinks per week (less than 2 glasses (300 mL) per drink)
  • No alcohol within three weeks of the experiment
  • Have no extended exposure to industrial wastes

Exclusion Criteria

  • Disease: gout, heart disease, peripheral vascular disease, degenerative kidney, degenerative liver, diabetes, GI disorders, or endocrine disorders
  • Cancer patients
  • Currently diagnosed cancer patients will be excluded.
  • Medication-free for >2 years could be considered.

Recruiting US locations

  • North Carolina Agriculture and Technical State University/ NRI Building

    Kannapolis, NC 28081

    Site contact: Samantha Caroll · 7047013024 · samantha_carroll@unc.edu

Study contacts (from the official record)

  • Shengmin Sang · 704-250-5710 · ssang@ncat.edu
All healthy volunteers studies in North Carolina →
Effects of Flavonoid Foods on Carbonyl Stress (NCT07767149) | Bored Studies