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Fluad vs. Fluzone High-Dose Vaccine Effectiveness Among Adults ≥65 Years

Kaiser Permanente · with Seqirus · NCT06029933

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 65+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
1500000
US sites recruiting
1
Study start
August 17, 2023
Record last updated
August 5, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study will evaluate the relative vaccine effectiveness of quadrivalent adjuvanted inactivated influenza vaccine (aIIV4) versus quadrivalent high-dose inactivated influenza vaccine (HD-IIV4) in preventing polymerase chain reaction (PCR)-confirmed influenza and influenza-related outcomes in adults ≥65 years of age during the 2023/24, 2024/25, and 2026/27 influenza seasons. The study is an observational study conducted at Kaiser Permanente Northern California (KPNC), an integrated health care system in the United States.

Being studied: Adjuvanted Quadrivalent Inactivated Influenza Vaccine (aIIV4); High-Dose Quadrivalent Inactivated Influenza Vaccine (HD-IIV4)

Conditions: Influenza; Community-acquired Pneumonia; Cardiovascular Events

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age ≥65 years at the time of influenza vaccination
  • KPNC member at the time of vaccination
  • Receive either aIIV4 or HD-IIV4 at a KPNC facility during the 2023/24 and/or 2024/25 influenza seasons

Exclusion Criteria

  • Age \<65 years at the time of influenza vaccination
  • Received either aIIV4 or HD-IIV4 in the inpatient setting
  • Receive more than one influenza vaccination during a single season period (i.e., 2023/24 or 2024/25 influenza seasons)
  • Receive an influenza vaccination outside of KPNC

Recruiting US locations

  • Kaiser Permanente Northern California (entire region)

    Oakland, CA 94612

    Site contact: Amber H. Hyman, PhD, MPH · (510) 267-7517 · Amber.Hyman@kp.org

Study contacts (from the official record)

  • Amber H. Hyman, PhD, MPH · 510-267-7571 · Amber.Hyman@kp.org
All vaccine studies in California →
Fluad vs. Fluzone High-Dose Vaccine Effectiveness Among Adults ≥65… (NCT06029933) | Bored Studies