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RecruitingAccepts healthy volunteersPhase 2

Hyperpolarized 129Xe MRI for Imaging Pulmonary Function

Bastiaan Driehuys · NCT01280994

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 2
Target enrollment
445
US sites recruiting
1
Study start
January 2011
Record last updated
January 16, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to develop and evaluate the usefulness of MRI using 129Xe gas for regional assessment of pulmonary function. Specifically, three forms of 129Xe MRI contrast will be the investigators focus - 1) imaging of the 129Xe ventilation distribution, 2) imaging the alveolar microstructure via the 129Xe apparent diffusion coefficient (ADC), and 3) imaging 129Xe that dissolves in the pulmonary blood and tissues upon inhalation. Such imaging of 129Xe gas transfer is expected to be uniquely sensitive to pathologies affecting gas exchange (fibrosis, emphysema, pulmonary hypertension) and provide new insights regarding the normal resting heterogeneity of pulmonary gas exchange.

Being studied: Hyperpolarized 129Xenon Gas

Conditions: Interstitial Lung Disease

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Inclusion Criteria for Healthy Control Subjects

  • Subject has no diagnosed pulmonary conditions
  • Subject has not smoked in the previous 5 years.
  • Smoking history, if any, is less than or equal to 5 pack-years.

Inclusion Criteria for Subjects with lung disease

  • Subject has a diagnosis of pulmonary dysfunction made by a physician
  • No acute worsening of pulmonary function in the past 30 days

Exclusion Criteria

  • Subject is less than 18 years old
  • MRI is contraindicated based on responses to MRI screening questionaire
  • Subject is pregnant or lactating
  • Respiratory illness of a bacterial or viral etiology within 30 days of MRI
  • Subject has received an investigational medicinal product (not including 129Xe) within 30 days of MRI
  • Subject has any form of known cardiac arrhythmia
  • Subject does not fit into 129Xe vest coil used for MRI
  • Subject cannot hold his/her breath for 15 seconds
  • Subject deemed unlikely to be able to comply with instructions during imaging

Recruiting US locations

  • Duke University Medical Center

    Durham, NC 27710

    Site contact: Bastiaan Driehuys, Ph.D

Study contacts (from the official record)

  • Jennifer Korzekwinski · 919-681-7362 · jennifer.korzekwinski@duke.edu
  • Cody Blanton · 919-668-7575 · cody.blanton@duke.edu
All healthy volunteers studies in North Carolina →
Hyperpolarized 129Xe MRI for Imaging Pulmonary Function (NCT01280994) | Bored Studies