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Inflammatory Challenge and Fear

University of California, San Francisco · with National Institute of Mental Health (NIMH), Northern California Institute of Research and Education · NCT06630884

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1
Target enrollment
288
US sites recruiting
1
Study start
March 28, 2025
Record last updated
September 21, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear. The main questions it aims to answer are:

Do people who receive typhoid vaccine respond differently than those who receive a placebo saline vaccine? Do people who receive typhoid vaccine experience changes in how they think and feel?

Participants will

Attend four appointments at the San Francisco VA Health Care System;

Receive typhoid vaccine or placebo at one of the visits;

Have their physiological responding measured while listening to sounds;

Complete questionnaires and psychological tests.

Being studied: Typhoid VI Polysaccharide Vaccine Injectable Solution; Saline Placebo (0.5mL injection)

Conditions: Posttraumatic Stress Disorder (PTSD)

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

All Subjects

  • Aged 18-65 years old
  • Trauma Exposed
  • Current PTSD/No history of PTSD

Exclusion Criteria

  • Contraindications to typhoid vaccine
  • Conditions associated with inflammation
  • Pregnancy or plans to become pregnant in next three months

Recruiting US locations

Study contacts (from the official record)

  • Aoife O'Donovan, PhD · 415-221-4810 · aoife.odonovan@ucsf.edu
  • Michael Srouji, BA · 415-221-4810
All mental health studies in California →
Inflammatory Challenge and Fear (NCT06630884) | Bored Studies