Mental health · California
Mental health studies in California
146 studies have at least one recruiting site in California. Mental health research includes studies of depression, anxiety, PTSD, bipolar disorder, schizophrenia and ADHD, testing medicines, devices and talk therapies.
146 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
5 studies with pay posted
Exact amounts posted by the research company for each study. The button opens that study’s own page.
Pays up to
$5,000
Schizophrenia Study
CenExel · Los Alamitos, CA
Ages 18–65 · Male/Female
View study & apply (opens in a new tab)Opens CenExel’s page for this exact study
Pays up to
$1,825
Bipolar Disorder Study
CenExel · Los Alamitos, CA
Ages 18–65 · Male/Female
View study & apply (opens in a new tab)Opens CenExel’s page for this exact study
Pays up to
$1,650
Depression Study
CenExel · Los Alamitos, CA
Ages 18+ · Male/Female
View study & apply (opens in a new tab)Opens CenExel’s page for this exact study
Pays up to
$1,125
Social Anxiety Study
CenExel · Sherman Oaks, CA
Ages 18–65 · Male/Female
View study & apply (opens in a new tab)Opens CenExel’s page for this exact study
Pays up to
$1,000
Major Depression Trials
CenExel · Sherman Oaks, CA
Ages 18–65 · Male/Female
View study & apply (opens in a new tab)Opens CenExel’s page for this exact study
More recruiting studies (pay not posted)
- RecruitingHealthy volunteersEarly Phase 1
Single and Multiple Ascending Doses of NTX-253 in Healthy Participants and Participants With Stable Schizophrenia
Neurosterix
- Location
- Los Alamitos, CA
- Eligibility basics
- Ages 18–55
- RecruitingPhase 1Overnight stay mentioned
A Study of LTX-001 In Adult Participants With Acute Exacerbation of Schizophrenia
Leal Therapeutics, Inc
- Location
- Los Alamitos, CA + 9 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingPhase 1Overnight stay mentioned
Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder
BioXcel Therapeutics Inc
- Location
- Anaheim, CA + 3 other US sites
- Eligibility basics
- Ages 10–17
- RecruitingHealthy volunteersPhase 1
Inflammatory Challenge and Fear
University of California, San Francisco
- Location
- San Francisco, CA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Mental Health in Veterans and Families After Group Therapies
Soul Medicine Institute
- Location
- Santa Rosa, CA
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
Imaging Synapses With [11C] UCB-J in the Human Brain
Davidzon, Guido, M.D.
- Location
- Palo Alto, CA + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteers
GUT-FEELINGS: Using Citizen Science for Large-Scale Prebiotic Clinical Trials for Mental Wellness in Adults
Holobiome, Inc.
- Location
- Del Mar, CA
- Eligibility basics
- Ages 21–80
- RecruitingHealthy volunteers
Observational Study of Decentralized Urine Optical Interaction Patterns Associated With Environmental Microplastic and Nanoplastic Exposure
Ecotera Health LLC
- Location
- San Francisco, CA + 50 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Decentralized Study to Evaluate a Dietary Supplement for Episodes of Mild Acute Stress in Healthy People
PLT Health Solutions
- Location
- San Francisco, CA
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 3
Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia
Reviva Pharmaceuticals
- Location
- Garden Grove, CA + 16 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 3
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder
Bristol-Myers Squibb
- Location
- Anaheim, CA + 18 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 3
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
Definium Therapeutics US, Inc.
- Location
- Orange, CA + 22 other US sites
- Eligibility basics
- Ages 18–74
- RecruitingPhase 3
A Study to Evaluate the Maintenance Effect of Osavampator as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Neurocrine Biosciences
- Location
- Oceanside, CA + 19 other US sites
- Eligibility basics
- Ages 18+
- Recruiting
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With…
LivaNova
- Location
- Costa Mesa, CA + 49 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)
Bristol-Myers Squibb
- Location
- Culver City, CA + 20 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 3
A Trial of the Efficacy and Safety of a Fixed Dose of SEP-363856 in Adults With Generalized Anxiety Disorder
Otsuka Pharmaceutical Development & Commercialization, Inc.
- Location
- Redlands, CA + 10 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2/Phase 3
ACP-204 in Adults With Alzheimer's Disease Psychosis
ACADIA Pharmaceuticals Inc.
- Location
- Costa Mesa, CA + 34 other US sites
- Eligibility basics
- Ages 55–95
- RecruitingPhase 4
A Study to Evaluate the Effect of KarXT on Urological Safety
Bristol-Myers Squibb
- Location
- Bellflower, CA + 12 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 4
A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)
Alpha Cognition, Inc
- Location
- Irvine, CA + 21 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 3
Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
- Location
- Anaheim, CA + 56 other US sites
- Eligibility basics
- Ages 55–90
- Recruiting
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Abbott Medical Devices
- Location
- Los Angeles, CA + 24 other US sites
- Eligibility basics
- Ages 22–70
- RecruitingPhase 3
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Cybin IRL Limited
- Location
- Glendale, CA + 27 other US sites
- Eligibility basics
- Ages 18–85
- RecruitingPhase 3
A Study to Evaluate the Long-term Safety and Tolerability of Xanomeline and Trospium Chloride for the Treatment of Psychiatric Disorders in Children and Adolescents
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
- Location
- Anaheim, CA + 12 other US sites
- Eligibility basics
- Ages 5–17
- RecruitingPhase 2
A Long-Term Open-Label Study of ML-007C-MA in Adults With Schizophrenia
MapLight Therapeutics
- Location
- Bellflower, CA + 41 other US sites
- Eligibility basics
- Ages 18–65
Who these studies look for
Studies usually require a confirmed diagnosis and stable circumstances, and they monitor safety closely. If you are in crisis, contact a crisis line or emergency services rather than a study.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Will joining affect my current treatment?
Some studies require changes to medicines, which the study team manages; others add to your usual care. Talk to your own clinician before making any change.