Skip to content
Bored Studies
RecruitingAccepts healthy volunteersPhase 2

Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy

Brigham and Women's Hospital · NCT06483659

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Phase 2
Target enrollment
152
US sites recruiting
1
Study start
June 1, 2025
Record last updated
August 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This is a randomized, double-blinded, placebo-controlled trial to compare the effectiveness of IV oxytocin infusion to placebo on peri-operative opioid consumption and reducing post-operative pain following a minimally invasive hysterectomy under general anesthesia.

Being studied: Oxytocin; Placebo

Conditions: Postoperative Pain

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Ages 18-65 years old
  • ASA category 1-3
  • Scheduled to undergo minimally invasive hysterectomy
  • No documented allergy to oxytocin

Exclusion Criteria

  • American Society of Anesthesiologists (ASA) group 4 or greater
  • Age >65 years old
  • Additional surgical procedures including but not limited to minor laparotomy, omentectomy, cystectomy, vaginectomy, and/or ablation of endometriosis.
  • Active opioid prescription of the equivalent of oxycodone >10 mg /day
  • Opioid use disorder, including patients in treatment receiving naltrexone or Suboxone (Buprenorphine-naloxone)
  • Allergies to any study medication: acetaminophen, celecoxib, ketorolac, fentanyl, hydromorphone, or oxycodone.
  • Epidural/Regional anesthesia for intra-operative or post-operative pain.
  • Inability to understand the questionnaires
  • Intra-operative and post-operative exclusion: Procedure converted to open or extension of primary surgery, Intra-operative EBL >500 ml., Placement of epidural catheter or regional anesthesia at PACU for pain management, Hospitalization of the patient due to surgical or anesthetic complications

Recruiting US locations

Study contacts (from the official record)

  • John J. Kowalczyk, MD · 617-732-8220 · jkowalczyk@bwh.harvard.edu
  • Rusul I Al-Ani · 617-525-6483 · rual-ani@bwh.harvard.edu
All pain studies in Massachusetts →
Intravenous Oxytocin for Post Operative Pain After Minimally… (NCT06483659) | Bored Studies