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Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury

Wake Forest University Health Sciences · with National Institute on Drug Abuse (NIDA) · NCT04810858

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 25–59 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
220
US sites recruiting
1
Study start
August 18, 2021
Record last updated
March 31, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.

Being studied: Multimodal, multi-parametric MRI; Immune and cytokine profiling; Neuropsychological testing

Conditions: Cannabis; HIV; Inflammation; Cognition; Neuroimaging

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • verified HIV status
  • Current marijuana use (MJ+ groups only)
  • No current marijuana use (MJ- groups only)
  • current engagement in HIV care (HIV+ participants only)
  • receipt of cART as first-line of treatment (HIV+ participants only)
  • stable cART regimen (HIV+ participants only)
  • undetectable HIV RNA viral load for >1 year (HIV+ participants only)

Exclusion Criteria

  • Lifetime abuse for any illicit drug other than marijuana
  • \<9th grade education; illiteracy or lack of fluency in English
  • history of moderate or severe head trauma
  • unstable or serious neurological disorders
  • severe mental illness
  • systemic autoimmune diseases
  • immunotherapy
  • MRI contraindications

Recruiting US locations

  • Biotech Place

    Winston-Salem, NC 27101

    Site contact: Christina S Meade, PhD · 336-716-0695 · Christina.Meade@wfusm.edu

Study contacts (from the official record)

  • Christina S Meade, PhD · 336-716-0695 · Christina.Meade@wfusm.edu
  • Sheri L Towe, PhD · 336-716-4331 · Sheri.Towe@wfusm.edu
All healthy volunteers studies in North Carolina →
Modeling the Effects of Chronic Marijuana Use on Neuroinflammation… (NCT04810858) | Bored Studies