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Nafamostat Efficacy in Phase 3 Registrational CRRT Study

Talphera, Inc · NCT06150742

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–80 · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Not applicable
Target enrollment
70
US sites recruiting
9
Study start
August 15, 2024
Record last updated
October 15, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

A prospective, randomized, placebo-controlled clinical study to investigate the safety and efficacy of Niyad (nafamostat mesylate) for anticoagulation of extracorporeal blood circulating through a dialysis filter in patients undergoing CRRT who cannot tolerate heparin or are at higher risk for bleeding.

Being studied: Niyad (nafamostat mesylate); Placebo (0.9% NaCl)

Conditions: Acute Kidney Injury

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Patients requiring CRRT or undergoing CRRT initiated within the prior 48 hours
  • Patients who cannot tolerate heparin or are at high risk of bleeding

Exclusion Criteria

  • Patients weighing less than 50 kg
  • Patients receiving systemic anticoagulation
  • Patients with active bleeding

Recruiting US locations

  • University of California Los Angeles

    Los Angeles, CA 90095

    Site contact: Senior Clinical Research Associate

  • Henry Ford Health

    Detroit, MI 48202

    Site contact: Clinical Study Coordinator

  • University of New Mexico

    Albuquerque, NM 87131

    Site contact: Nurse Research Coordinator

  • Northwell Health

    Great Neck, NY 11021

    Site contact: Clinical Research Coordinator

  • Mount Sinai

    New York, NY 10029

    Site contact: Clinical Research Assistant

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, OH 45229

    Site contact: Clinical Research Manager

  • University of Pittsburgh Medical Center

    Pittsburgh, PA 15213

    Site contact: Assistant Director, Laboratory Operations

  • Medical University of South Carolina

    Charleston, SC 29425

    Site contact: Clinical Research Coordinator

  • Baylor University Medical Center

    Dallas, TX 75246

    Site contact: Research Nurse 1

Study contacts (from the official record)

  • Nazneen Patel · 647-724-5709 · nazneen.patel@clinchoice.com
  • Chris Houchins · chris.houchins@clinchoice.com
Nafamostat Efficacy in Phase 3 Registrational CRRT Study (NCT06150742) | Bored Studies