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Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness

Massachusetts General Hospital · with Boston University · NCT04940663

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–55 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
120
US sites recruiting
1
Study start
July 13, 2022
Record last updated
July 16, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions among these experiences in daily life and how they, and their neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutics aimed at improving functioning and overall quality of life in individuals with serious mental illnesses, as well as quantitative phenotypes for use in early detection efforts.

Being studied: EMA

Conditions: Psychosis; Schizophrenia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 18-55 years old
  • Experienced a psychotic disorder or mood disorder

Exclusion Criteria

  • Any neurological disorder or current substance use disorder (during the past 6 months)
  • Not proficient in English
  • A recent change in medication, or an acute symptom presentation
  • Standard exclusion criteria for participation in an MRI scan (e.g., presence of metal in the body, claustrophobia, a history of head trauma).

Recruiting US locations

  • Massachusetts General Hospital

    Charlestown, MA 02129

    Site contact: Daphne J Holt, MD, PhD · 617-726-7618 · dholt@mgh.harvard.edu

Study contacts (from the official record)

  • Daphne J Holt, MD, PhD · 617-726-7618 · dholt@partners.org
All mental health studies in Massachusetts →
Neurobehavioral Mechanisms of Social Isolation and Loneliness in… (NCT04940663) | Bored Studies