Mental health · Massachusetts
Mental health studies in Massachusetts
84 studies have at least one recruiting site in Massachusetts. Mental health research includes studies of depression, anxiety, PTSD, bipolar disorder, schizophrenia and ADHD, testing medicines, devices and talk therapies.
84 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 1/Phase 2Overnight stay mentioned
A Study to Investigate Lithium Brain/Plasma Pharmacokinetics and Safety of an AL001 Oral Capsule Compared to a Marketed Immediate-release Lithium Carbonate Capsule in Subjects With Bipolar I Disorder
Alzamend Neuro, Inc.
- Location
- Boston, MA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1/Phase 2
PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases
Brigham and Women's Hospital
- Location
- Boston, MA
- Eligibility basics
- Ages 18–85
- RecruitingHealthy volunteers
Observational Study of Decentralized Urine Optical Interaction Patterns Associated With Environmental Microplastic and Nanoplastic Exposure
Ecotera Health LLC
- Location
- Boston, MA + 50 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 3
REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool
Senseye, Inc.
- Location
- Boston, MA + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Apple Health Study
Apple Inc.
- Location
- Boston, MA + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 3
Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia
Reviva Pharmaceuticals
- Location
- Boston, MA + 16 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 3
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
Definium Therapeutics US, Inc.
- Location
- Boston, MA + 22 other US sites
- Eligibility basics
- Ages 18–74
- Recruiting
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With…
LivaNova
- Location
- Boston, MA + 49 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2/Phase 3
A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial
NeuroRx, Inc.
- Location
- Belmont, MA + 2 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingPhase 3
A Trial of the Efficacy and Safety of a Fixed Dose of SEP-363856 in Adults With Generalized Anxiety Disorder
Otsuka Pharmaceutical Development & Commercialization, Inc.
- Location
- Watertown, MA + 10 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 4
A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)
Alpha Cognition, Inc
- Location
- Methuen, MA + 21 other US sites
- Eligibility basics
- Ages 50+
- Recruiting
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Abbott Medical Devices
- Location
- Boston, MA + 24 other US sites
- Eligibility basics
- Ages 22–70
- RecruitingPhase 3
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Cybin IRL Limited
- Location
- Boston, MA + 27 other US sites
- Eligibility basics
- Ages 18–85
- RecruitingPhase 3
A Study to Evaluate the Long-term Safety and Tolerability of Xanomeline and Trospium Chloride for the Treatment of Psychiatric Disorders in Children and Adolescents
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
- Location
- Boston, MA + 12 other US sites
- Eligibility basics
- Ages 5–17
- RecruitingPhase 2
A Long-Term Open-Label Study of ML-007C-MA in Adults With Schizophrenia
MapLight Therapeutics
- Location
- Boston, MA + 41 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
Draig Therapeutics Ltd
- Location
- Boston, MA + 19 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 2
ALTO-100 in Bipolar Disorder With Depression (BD-D)
Alto Neuroscience
- Location
- Worcester, MA + 38 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 3
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
Axsome Therapeutics, Inc.
- Location
- Springfield, MA + 35 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 3
Forward Treatment of Attention Deficit and Hyperactivity Using Solriamfetol (FOCUS-2)
Axsome Therapeutics, Inc.
- Location
- Springfield, MA + 28 other US sites
- Eligibility basics
- Ages 6–11
- RecruitingPhase 3
Forward Treatment of Attention Deficit and Hyperactivity Using Solriamfetol (FOCUS-3)
Axsome Therapeutics, Inc.
- Location
- Springfield, MA + 27 other US sites
- Eligibility basics
- Ages 12–17
- RecruitingPhase 2
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
Draig Therapeutics Ltd
- Location
- Watertown, MA + 18 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 2
A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)
Eli Lilly and Company
- Location
- Springfield, MA + 19 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 2
A Study of Brenipatide in Adult Participants With Schizophrenia
Eli Lilly and Company
- Location
- Belmont, MA + 31 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingPhase 3
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
Eli Lilly and Company
- Location
- Boston, MA + 28 other US sites
- Eligibility basics
- Ages 18–75
Who these studies look for
Studies usually require a confirmed diagnosis and stable circumstances, and they monitor safety closely. If you are in crisis, contact a crisis line or emergency services rather than a study.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Will joining affect my current treatment?
Some studies require changes to medicines, which the study team manages; others add to your usual care. Talk to your own clinician before making any change.