Vaccine · Massachusetts
Vaccine studies in Massachusetts
17 studies have at least one recruiting site in Massachusetts. Vaccine trials test how well new or updated vaccines produce an immune response and how they are tolerated. Many recruit healthy adults; some focus on older adults, children or people with specific conditions.
17 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1/Phase 2
Phase 1/2 Study of Respiratory Syncytial Virus and Human Metapneumovirus (RSV+HMPV) Vaccine Candidate in Adults 60 Years of Age and Older
Sanofi
- Location
- Boston, MA + 49 other US sites
- Eligibility basics
- Ages 60+
- RecruitingHealthy volunteersPhase 1
A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant
City of Hope Medical Center
- Location
- Boston, MA + 2 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Boston, MA + 4 other US sites
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersPhase 1
Phase 1 Study of CH505 HIV Vaccine Nanoparticles and mRNA Boosters in Healthy Adults
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Boston, MA + 1 other US site
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Clinical Study to Investigate the Safety and Immunogenicity of rVSV∆G-SUDV-GP, a Sudan Virus (SUDV) Vaccine for the Prevention of SUDV Disease in Adults in Good General Health
International AIDS Vaccine Initiative
- Location
- Boston, MA + 2 other US sites
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteersPhase 1
Clinical Trial to Evaluate the Safety and Immunogenicity of the V2 Apex-Directed Immunogens DV201P-RNA and DV202B1-RNA in Adult Participants Without HIV
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Boston, MA + 6 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 3
A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose
Pfizer
- Location
- Boston, MA + 76 other US sites
- Eligibility basics
- Ages 0 mo+
- RecruitingHealthy volunteersPhase 3
A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older
Pfizer
- Location
- West Roxbury, MA + 138 other US sites
- Eligibility basics
- Ages 65+
- RecruitingHealthy volunteersPhase 3
BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies
Pfizer
- Location
- Boston, MA + 111 other US sites
- Eligibility basics
- Ages 0 mo–49
- RecruitingHealthy volunteersPhase 3
A Study on the Efficacy of a Vaccine Against Influenza in Adults ≥65 Years of Age
GlaxoSmithKline
- Location
- Boston, MA + 130 other US sites
- Eligibility basics
- Ages 65+
- RecruitingHealthy volunteersPhase 3
A Study to Learn About the Safety of an Expanded Pneumococcal Vaccine in Healthy Infants
Pfizer
- Location
- Fall River, MA + 20 other US sites
- Eligibility basics
- Ages 1 mo–4 mo
- RecruitingHealthy volunteersPhase 3
Study to Learn About Safety, Tolerability, and Immune Response of a Catch-up Pneumococcal Vaccine in Children and Adolescents
Pfizer
- Location
- Fall River, MA + 49 other US sites
- Eligibility basics
- Ages 1–17
- RecruitingHealthy volunteersPhase 3
A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine When Given to Healthy Children 12 to 15 Months of Age
GlaxoSmithKline
- Location
- Fall River, MA + 46 other US sites
- Eligibility basics
- Ages 1–1
- RecruitingHealthy volunteersPhase 3
A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lyme Disease Vaccine
Pfizer
- Location
- Worcester, MA + 10 other US sites
- Eligibility basics
- Ages 7+
- RecruitingPhase 1/Phase 2
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne
Sanofi Pasteur, a Sanofi Company
- Location
- Brighton, MA + 78 other US sites
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersPhase 2
CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant
City of Hope Medical Center
- Location
- Boston, MA + 2 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteers
ARISe at UMass Chan
University of Massachusetts, Worcester
- Location
- Worcester, MA
- Eligibility basics
- Ages 18+
Who these studies look for
Vaccine studies often exclude people who recently received a related vaccine or had the infection, and those with conditions or medicines that affect the immune system.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Could I receive a placebo?
Often yes. Many vaccine trials are randomized, so some participants receive a comparison vaccine or placebo. The consent document explains this.